HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1290 Ziftomenib Ziftomenib (KO-539) is an oral inhibitor of menin targeting the menin–KMT2A protein-protein interaction. It exhibits antileukemic activity and induces apoptosis of acute myeloid leukemia(AML) cells. Jul 11 2024
E4819 Afatinib free base Afatinib free base (Gilotrif, BIBW2992, Boehringer Ingelheim) is a second-generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 14 nM and 1 nM for wild-type EGFR, EGFR-L858R, HER2, ErbB4, respectively. Jul 11 2024
E1867 NPD4928 NPD4928 is an inhibitor of Ferroptosis Suppressor Protein 1 (FSP1) that enhances ferroptosis. It enhances the cytotoxic effects on various cell types when combined with GPX4 antagonists. Jul 11 2024
E4816 Choline hydroxide, 42.5 wt.% in water Choline hydroxide, 42.5 wt.% in water, is a strong organic base used as a metal-free, nontoxic, and water-soluble catalyst. It facilitates the synthesis of 1,8-naphthyridine derivatives while avoiding the use of hazardous or carcinogenic organic solvents. Jul 10 2024
E1975 HC-7366 HC-7366, is a First-in-Human modulator of General controlled nonderepressible 2 (GCN2) that activates GCN2. It demonstrates anti-metastatic efficacy, reducing lung metastases and exhibits anti-tumor activity. Jul 09 2024
A2163 Anti-mouse IL-12 p40-InVivo Anti-mouse IL-12 p40-InVivo reacts with mouse p40 also known as IL-12β. p40 is a 40 kDa subunit of IL-12 and IL-23. IL-12 is a heterodimeric cytokine composed of subunits IL-12α p35 and IL-12β p40. Jul 09 2024
A2164 Anti-mouse B220-InVivo Anti-mouse B220-InVivo reacts with mouse B220 also known as CD45R. B220 is a 220 kDa transmembrane protein tyrosine phosphatase expressed on B cells and some subsets of T and NK cells. Jul 09 2024
E4805 Methylene Blue trihydrate Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy. Jul 08 2024
E4807 Dexketoprofen trometamol Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective inhibitor of COX. Dexketoprofen trometamol exhibits analgesic efficacy and can be used in treating acute pain. Jul 08 2024
E4811 Levofloxacin hydrochloride Levofloxacin hydrochloride ((-)-Ofloxacin hydrochloride), a synthetic fluoroquinolone antibiotic, is an inhibitor of DNA gyrase and Topoisomerase IV. It exhibits bactericidal effects by preventing bacterial DNA replication. Jul 08 2024
E4812 Fluoxetine Fluoxetine (LY-110140 free base) is a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine is used widely in the treatment of depression, anxiety-related symptoms and also displays anticonvulsant activity. Jul 08 2024
E1987 APX2009 APX2009 is a second-generation redox-specific inhibitor of APE1/Ref-1, an essential enzyme in the base excision repair (BER) pathway. APX2009 effectively reduces breast cancer cell proliferation and colony formation. Jul 08 2024
E1944 INS018-055(ISM001-055) INS018-055 (ISM001-055, TNIK&MAP4K4-IN-2, compound 112) is an inhibitor of TNIK and MAP4K4. It exhibits an IC50 values of 12-120 nM on TNIK. Jul 08 2024
E1854 INX-315 INX-315 is an orally active and selective inhibitor of CDK2 that induces cell cycle arrest in the G1 phase. It exhibits an IC50 value of 2.3 nM in intracellular NanoBRET assay, respectively. It displays a 50-fold increased CDK2 selectivity compared to CDK1. INX-315 decreases the phosphorylation of CDK2 substrates and suppresses tumor growth in xenograft mouse models in a dose-dependent manner. Jul 05 2024
E1900 Simnotrelvir Simnotrelvir(SIM0417, SARS-CoV-2-IN-41) is an inhibitor of coronavirus main proteinase (3CLpro) (SARS-CoV-2 3CLpro) with an IC50 of 24 nM. It has a potential anti-SARS-CoV-2 activity. Jul 04 2024
E4809 Piperaquine tetraphosphate tetrahydrate Piperaquine tetraphosphate tetrahydrate is an inhibitor of autophagy . It is a bisquinoline antimalarial agent effective against Plasmodium falciparum. Piperaquine tetraphosphate tetrahydrate is useful in antimalarial research. Jul 04 2024
E4808 Propionyl-L-carnitine hydrochloride Propionyl-L-carnitine hydrochloride(Levocarnitine propionate hydrochloride) supports mitochondrial metabolism, offers cardiovascular benefits, acts as a free radical scavenger, and is used in treating colonic inflammatory bowel disease. Jul 04 2024
E4810 Piperacillin Piperacillin is a broad-spectrum β-lactam antibiotic with potent bactericidal activity against Gram-negative bacteria and selects Gram-positive strains via penicillin-binding proteins. Jul 04 2024
E4634 MIRA-1 MIRA-1(NSC 19630), a maleimide compound, is a selective inhibitor of Werner syndrome WRN helicase activity with an IC50 of 20 µM while sparing ATPase and exonuclease activities. It reactivates mutant p53, inducing apoptosis in various human solid tumor cell lines with tetracycline-regulated mutant p53. Jul 03 2024
E4803 Vardenafil Vardenafil is an orally active and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 value of 0.7 nM, respectively. Vardenafil acts as a competitive inhibitor of cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. Vardenafil can be used for the research of erectile dysfunction, hepatitis, diabetes. Jul 02 2024