HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1921 NRL-1049 NRL-1049(BA 1049) is a small molecule selective inhibitor of ROCK2 with an IC50 of 0.59 µM. It exhibits potent efficacy in preserving the blood-brain barrier (BBB) and suppresses seizures after brain injury, and inhibits hemorrhagic transformation after ischemic stroke in mice. Dec 12 2024
E4782 17-OH PREG (17a-Hydroxypregnenolone) 17-OH PREG (17a-Hydroxypregnenolone) is a pregnenolone metabolite and DHEA precursor. It is formed through CYP17A1 hydroxylase and 17,20-lyase activities. It is the most relevant steroid for the study of elevated plasma levels linked to type II 3β-hydroxysteroid dehydrogenase deficiency. Dec 12 2024
E5775 Exatecan Exatecan (DX-8951), is a water-soluble derivative of camptothecin. It acts as an inhibitor of DNA topoisomerase I with an IC50 value of 1.906 μM. It demonstrates potent antitumor effects and triggers apoptotic cell death after treatment in human pancreatic cancer cells. Dec 11 2024
E4997 BAY 2927088（Sevabertinib） BAY 2927088（Sevabertinib) is the first non-covalent, potent, oral, selective, and reversible inhibitor of tyrosine kinase that potently inhibits mutant HER2 and mutant EGFR in preclinical models. It targets Exon 20 insertions in non-small-cell lung carcinoma (NSCLC) patients. Dec 11 2024
E5777 Tris(benzyltriazolylmethyl)amine Tris(benzyltriazolylmethyl)amine (TBTA) is a ligand used as a biochemical tool for labeling proteins and enzymes. It dramatically enhances the Copper(II) acetate (Cu(OAc)2)-accelerated azide-alkyne cycloaddition (AAC) reactions involving nonchelating azides. Dec 11 2024
E5767 Ovalbumins Ovalbumin is a major glycoprotein found in egg whites, serving as a nutrient reserve for developing embryos and used in the food industry. It also induces a Th2 immune response in sensitized individuals, characterized by the production of cytokines like IL-4, IL-5, and IL-13, leading to airway inflammation, hyper-responsiveness (AHR), and immune cell infiltration, key features in asthma models. Dec 11 2024
P1246 ODN 1826 sodium ODN 1826 sodium (CpG 1826 sodium) is a synthetic CpG oligodeoxynucleotide and agonist of TLR9 signaling pathway, that induces G1-phase arrest and apoptosis in A20 lymphoma cells while stimulating NO and iNOS production in mouse models, as part of its immunostimulatory activity. Dec 11 2024
S9740 U0126 U0126 is a highly potent and selective inhibitor of the dual-specificity kinases MEK1 and MEK2, with IC50 values of 72 nM and 58 nM, respectively. It also acts as a strong antioxidant, protecting cells from oxidative stress-induced cell death. Dec 05 2024
E4702 SRX3177 SRX3177 is a potent triple inhibitor targeting CDK4/6, PI3K, and BRD4, with IC50 values of 33 nM for BRD4 BD1, 89 nM for BRD4 BD2, 79 nM for PI3Kα, 83 nM for PI3Kδ, 3.18 μM for PI3Kγ, <2.5 nM for CDK4, and 3.3 nM for CDK6. By simultaneously inhibiting these key pathways, SRX3177 disrupts cancer cell signalling and exhibits significant cytotoxic effects in tumors. Dec 05 2024
E4621 BHPI BHPI is a potent noncompetitive inhibitor of estrogen receptor α (ERα), which disrupts the protective estrogen–ERα-mediated activation of the unfolded protein response (UPR), leading to sustained UPR activation. It specifically inhibits the growth of drug-resistant ERα-positive breast and ovarian cancer cells and induces significant tumor regression in a mouse xenograft model of breast cancer. Dec 05 2024
E4785 BAP1-IN-1 BAP1-IN-1 is a small-molecule inhibitor of BRCA1 associated protein 1 (BAP1) catalytic activity in vitro with an IC50 of 0.1-1 μM. It exhibits a potential therapeutic target for leukemia. Dec 05 2024
E1939 ART899 ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells. Dec 05 2024
E4774 4-DAMP 4-DAMP (4-diphenyl-acetoxy-N-methyl-piperidine) (4-DAMP methiodide) is a selective antagonist of M3 type muscarinic acetylcholine receptors (M3-mAChR) with a pKi of 9.3. It also has a high affinity for the closely-related M5 receptor with a pKi of 8.9. It is routinely used to study the regulation and functions of the M3 receptor. Dec 05 2024
E4732 FDW028 FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities. Dec 02 2024
E4880 Labetalol Labetalol (AH5158, Sch-15719W free base) is an orally active and selective competitive antagonist of α1-adrenergic receptors and non-selective β-adrenergic receptors. Labetalol, an anti-hypertensive agent is used in the research of cardiovascular diseases. Dec 02 2024
E1896 BMS-502 BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 values of 4.6 nM and 2.1 nM, respectively. BMS-502 also exhibits an EC50 value of 340 nM in the mouse cytotoxic T cell IFN-γ assay (mCTC). BMS-502 can be used in tumor immunity-related research. Dec 02 2024
E6005 Saxagliptin hydrochloride Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4). It exhibits 400-950 fold selective inhibition of DPP-4 than DPP-8. Saxagliptin hydrochloride is used in the research of type 2 diabetes mellitus research. Dec 02 2024
E1664 GNE-987 GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase. It exhibits BRD4 degradation activity with DC50 of 0.03 nM for the EOL-1 AML cell line. GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets. It also demonstrates potent antitumor activity in AML cell lines. Dec 02 2024
E6006 Deferasirox (Fe3+ chelate) Deferasirox (Fe3+ chelate) (Exjade) is an oral tridentate iron chelator used for reducing transfusional chronic iron overload. It exhibits efficacy in iron-overloaded patients with anemias, thalassemia, sickle cell disease and myelodysplastic syndromes. It is also an orally effective antitumor agent against solid tumors. Nov 29 2024
E4884 Icotinib Hydrochloride Icotinib hydrochloride (BPI-2009H) is a highly potent and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 5 nM, utilized in the treatment of non-small cell lung cancer (NSCLC). Nov 29 2024