HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1015 Angiotensin II human Angiotensin II human is a potent vasoconstrictor that induces angiogenesis by activating angiotensin II type 1 (AT1) receptor, which increases the production of vascular endothelial growth factor (VEGF) in a redox-sensitive manner and promotes the formation of capillaries from endothelial cells through the LOX-1-dependent redox-sensitive pathway. Jul 23 2024
E4837 Trimethoprim (lactate) Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs). Jul 23 2024
E4647 Aticaprant Aticaprant (CERC-501, LY-2456302) is a potent, orally bioavailable, centrally-penetrant antagonist of the kappa opioid receptor with a Ki of 0.807 nM. It exhibits an antidepressant effect with the potential to treat major depressive disorder (MDD). Jul 23 2024
E1957 NX-1607 NX-1607 (Cbl-b-IN-3) is an oral inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), which is an E3 ubiquitin ligase and a key regulator of T, NK, and dendritic cell activation and suppresses their anti-tumor functions. NX-1607 enhances antigen recall, reduces T cell exhaustion, and increases cytokine production in response to T cell receptor stimulation, thereby counteracting suppressive signals from the tumor microenvironment. Jul 23 2024
E4826 L-Ornithine L-aspartate L-ornithine-L-aspartate (LOLA) is a stable salt composed of two natural nonessential L-amino acids: ornithine and aspartic acid. It effectively lowers blood ammonia concentration by enhancing ammonia detoxification in the muscles, and alleviating hepatic encephalopathy symptoms in liver cirrhosis. Jul 19 2024
E4822 Tacrine Tacrine is a potent acetylcholinesterase (AChE) inhibitor. It inhibits acetylcholinesterase(AChE) and butyrylcholinesterase(BChE) with an IC50 of 77 nM and 69 nM, respectively. It is used in the treatment of Alzheimer's disease (AD), also poisoning topoisomerases and inhibiting in vivo (mitochondrial)mtDNA synthesis. Jul 19 2024
E4832 DL-Alanine DL-alanine (DL-2-Aminopropionic acid) is a racemic mixture of L- and D-alanine that forms complexes with transition metals like Cu(II), Zn(II), and Cd(II). It also plays a key role in the glucose-alanine cycle between tissues and the liver. Jul 19 2024
E4831 L-Arginine (L-glutamate) L-Arginine (L-glutamate) (Arginine glutamate) is a mixture of amino acids that induces apoptosis via hypertonic stress. It also promotes gastric relaxation by providing L-arginine for nitric oxide production, thereby benefiting gastrointestinal motility and conditions associated with vagus nerve dysfunction. Jul 19 2024
E4830 Guanidine thiocyanate Guanidine thiocyanate is a potent inhibitor of nucleases and a powerful denaturant of proteins. It is used for RNA isolation due to its strong chaotropic properties, which effectively denature RNase enzymes in samples, ensuring RNA stability and purity during extraction processes. Nucleic acid extraction buffers containing guanidine thiocyanate effectively deactivate high-titer polioviruses found in potentially infectious materials. Jul 19 2024
E4825 Naphazoline (nitrate) Naphazoline (nitrate) is a agonist of peripheral α2-adrenergic receptor and used as a topical decongestant. It also acts as a vasoconstrictor that effectively reduces intraoperative bleeding and enhances postoperative analgesia. When used in conjunction with intranasal lidocaine, it significantly reduces both intra- and postoperative pain, thereby decreasing the need for rescue analgesics in the postoperative period following septorhinoplasty. Jul 19 2024
E4828 Cloperastine fendizoate Cloperastine fendizoate (Hustazol) is a sedative used to relieve cough and also has a peripheral action that desensitizes the afferent nerves in the tracheobronchial region. It inhibits the hERG K+ currents in a concentration-dependent manner, with an IC50 value of 0.027 μM. Jul 19 2024
E4824 Hydroxychloroquine Hydroxychloroquine (HCQ) is an antimalarial drug that inhibits autophagy and is used to treat systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). It exhibits immunomodulatory, antithrombotic, and antiplatelet properties. It inhibits the release endothelin-1, a potent vasoconstrictor, and restores impaired angiogenesis in TNF-α-treated endothelial cells in vitro. It also reduces the production of inflammatory cytokines such as TNF-α, IFN-γ, and IL-6 from peripheral blood mononuclear cells, upregulates IL-10 and decreases platelet aggregation. Jul 19 2024
E4806 Quinine dihydrochloride Quinine dihydrochloride is an antiparasitic used to treat malaria and is particularly important for managing malaria during the first trimester of pregnancy. It inhibits Slo3 (KCa 5.1) channel, which are a significant part of the mammalian KSper (sperm potassium conductance), by binding to hydrophobic side chains located at the intracellular region of the channel pore. Jul 19 2024
E1885 LY3522348 LY3522348 is a highly selective oral dual inhibitor of the human ketohexokinase isoforms C and A, with IC50 values of 20nM for hKHK-C and 24nM for hKHK-A. It shows a significant pharmacodynamic effect in a mouse model of fructose metabolism. Jul 19 2024
E1686 SW-100 SW-100 is a selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 2.3 nM. It displays 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Jul 18 2024
E4630 Ilginatinib hydrochloride Ilginatinib hydrochloride (NS-018 hydrochloride) is a potent small-molecule inhibitor of JAK2 that is competitive with adenosine triphosphate (ATP) which exhibits 30–50-fold greater selectivity for JAK2 over other Jak-family kinases such as JAK1, JAK3, and TYK2.It inhibits JAK2, JAK1, JAK3, and TYK2 with IC50 of 0.72 nM, 33 nM, 39 nM, and 22 nM, respectively. It also showed potent inhibition of Src-family kinases, SRC and FYN. It can be used in research of myeloproliferative neoplasms. Jul 18 2024
E4823 Pargyline Pargyline is an irreversible selective inhibitor of monoamine oxidase (MAO) with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B respectively. It has pharmaceutical potential as an anticancer drug for human prostate cancer. Jul 18 2024
E4829 Bismuth subnitrate Bismuth subnitrate is an antigastric ulcer and antidiarrheic agent that induces metallothionein (MT). It can be used as an adjunct in cancer chemotherapy to induce MT in target organs. Jul 18 2024
P1241 Bromelain Bromelain is an aqueous extract of pineapple that is composed of 95%-mixture of proteases, acting as an inhibitor of Prostaglandin E2 (PGE2) and Cox-2. It exhibits potent anti-inflammatory, anti-thrombotic, fibrinolytic and anti-cancer functions. Jul 18 2024
E4592 UGT8-IN-1 UGT8-IN-1 is a brain-penetrable and orally active inhibitor of ceramide galactosyltransferase enzyme (UGT8). UGT8-IN-1 targets sulfatide metabolism resulting in ceramide-induced lethal mitophagy and subsequent cancer cell death in vitro, and reduces tumour growth in mutant Kras; Gnas allografts. Jul 16 2024