Home JAK/STAT JAK inhibitor - Src inhibitor Ilginatinib hydrochloride For research use only.

Ilginatinib hydrochloride

Synonyms: NS-018 hydrochloride

Ilginatinib hydrochloride (NS-018 hydrochloride) is a potent small-molecule inhibitor of JAK2 that is competitive with adenosine triphosphate (ATP) which exhibits 30–50-fold greater selectivity for JAK2 over other Jak-family kinases such as JAK1, JAK3, and TYK2.It inhibits JAK2, JAK1, JAK3, and TYK2 with IC50 of 0.72 nM, 33 nM, 39 nM, and 22 nM, respectively. It also showed potent inhibition of Src-family kinases, SRC and FYN. It can be used in research of myeloproliferative neoplasms.

Ilginatinib hydrochloride Chemical Structure

Ilginatinib hydrochloride Chemical Structure

CAS No. 1239358-85-0

Purity & Quality Control

Batch: E463001 DMSO]85 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.02%
99.02

Ilginatinib hydrochloride Related Products

Signaling Pathway

JAK Signaling Pathways

JAK Signaling Pathway

Biological Activity

Description Ilginatinib hydrochloride (NS-018 hydrochloride) is a potent small-molecule inhibitor of JAK2 that is competitive with adenosine triphosphate (ATP) which exhibits 30–50-fold greater selectivity for JAK2 over other Jak-family kinases such as JAK1, JAK3, and TYK2.It inhibits JAK2, JAK1, JAK3, and TYK2 with IC50 of 0.72 nM, 33 nM, 39 nM, and 22 nM, respectively. It also showed potent inhibition of Src-family kinases, SRC and FYN. It can be used in research of myeloproliferative neoplasms.

Chemical Information & Solubility

Molecular Weight 425.89 Formula

C21H20FN7.ClH
CAS No. 1239358-85-0 SDF Download Ilginatinib hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 85 mg/mL ( (199.58 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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