Home JAK/STAT JAK inhibitor Curcumol For research use only.

Curcumol

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.

Curcumol Chemical Structure

Curcumol Chemical Structure

CAS No. 4871-97-0

Curcumol Related Products

Signaling Pathway

JAK Signaling Pathways

JAK Signaling Pathway

Biological Activity

Description Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
Targets
JAK [2]
In vitro
In vitro Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. [1] Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities. [2]

Chemical Information & Solubility

Molecular Weight 236.35 Formula

C15H24O2
CAS No. 4871-97-0 SDF Download Curcumol SDF
Smiles CC1CCC2C13CC(C(O3)(CC2=C)O)C(C)C
Storage (From the date of receipt)

In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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