Home DNA Damage/DNA Repair DHFR inhibitor Trimethoprim (lactate) For research use only.

Trimethoprim (lactate)

Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs).

Trimethoprim (lactate) Chemical Structure

Trimethoprim (lactate) Chemical Structure

CAS No. 23256-42-0

Purity & Quality Control

Batch: E483701 DMSO]76 mg/mL]false]Water]76 mg/mL]false]Ethanol]12 mg/mL]false Purity: 99.19%
99.19

Trimethoprim (lactate) Related Products

Signaling Pathway

DHFR Signaling Pathways

DHFR Signaling Pathway

Biological Activity

Description Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, trimethoprim prevents the synthesis of bacterial DNA, hindering bacterial survival. It is a standard antibiotic for treating urinary tract infections (UTIs).
Targets
DHFR [1]

Chemical Information & Solubility

Molecular Weight 380.40 Formula

C14H18N4O3.C3H6O3
CAS No. 23256-42-0 SDF Download Trimethoprim (lactate) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 76 mg/mL

Ethanol : 12 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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