HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E1815 STX-478 STX-478 is a highly potent, mutant-selective, allosteric inhibitor of PI3Kα, that selectively targets prevalent mutant forms of PI3Kα. It demonstrates strong efficacy against common PI3Kα helical- and kinase-domain mutations, including the H1047R variant, with an IC50 value of 9.4 nmol/L. STX-478 exhibits 14-fold greater selectivity for mutant PI3Kα over the wild-type form. It spares metabolic dysfunction and improves therapeutic response in PI3Kα-Mutant Xenografts. Nov 14 2024
E4922 Allopurinol riboside Allopurinol riboside, a metabolite of allopurinol, competitively inhibits the action of purine nucleoside phosphorylase on inosine in vitro with a Ki value of 277 μM. It displays potent activities against parasites. Nov 14 2024
E1979 Irpagratinib Irpagratinib (ABSK011) is a potent inhibitor of FGFR4 with an IC50 of < 10 nM in biochemical assays. It effectively suppresses FGFR4 auto-phosphorylation and disrupts downstream signal transduction. It also strongly inhibits tumor growth and induces regression in subcutaneous xenograft models. Nov 14 2024
E4740 TAK-861 TAK-861 is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM. Nov 14 2024
E6017 Ornidazole (Levo-) Ornidazole (Levo-) (Levornidazole, (S)-Ornidazole), the levo-isomer of ornidazole, is a third-generation nitroimidazole derivative. It exhibits antiprotozoal and antibacterial properties against anaerobic bacteria. Nov 14 2024
P1245 Bovine Serum Albumin Bovine serum albumin (BSA, Albumin bovine serum) is an efficient passivating agent that inhibits nonspecific protein binding in assays such as ELISA. It is used to coat hydrophobic substrates, enhancing anti-fouling properties and reducing immune system interactions. Nov 14 2024
E4976 Tegaserod Tegaserod is an orally active agonist of serotonin receptor 4 (5-HT4R) and also acts as an antagonist of 5-HT2B receptor with pKi values of 7.5, 8.4, and 7.0 for human recombinant 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Tegaserod has anti-tumor activity and is used in the research of irritable bowel syndrome (IBS). Nov 12 2024
E4983 Omadacycline hydrochloride Omadacycline hydrochloride (PTK0796 hydrochloride) is a first-in-class orally active member of the tetracycline class of antibiotics. Omadacycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride exhibits broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Nov 12 2024
E1272 SRI-37330 HCl SRI-37330 HCl(EX-A5854), an anti-diabetic drug, is an orally bioavailable inhibitor of thioredoxin-interacting protein (TXNIP), with an IC50 of 0.64 μM for TXNIP expression in INS-1 cells. Its treatment inhibits glucagon secretion and function, decreases hepatic glucose production, and reverses hepatic steatosis. Nov 07 2024
E1758 Bersacapavir Bersacapavir(JNJ-6379, JNJ-56136379) is a potent capsid assembly modulator (CAM) that accelerates capsid assembly and induces the formation of morphologically intact viral capsids devoid of genomic material. It inhibits HBV replication with an EC50 of 54 nM in HepG2.117 cells. Nov 07 2024
E1510 Sonrotoclax Sonrotoclax(BGB-11417) is a highly potent, orally active and selective inhibitor of Bcl2. Sonrotoclax demonstrates increased potency along with in vitro and in vivo inhibitory activity against both WT Bcl-2 and the G101V mutant. Bcl-xL Sonrotoclax has effective cell killing effect against a variety of lymphoma and leukemia cell lines. Nov 05 2024
S5970 Selenomethionine Selenomethionine (Seleno-DL-methionine, DL-Selenomethionine) is a naturally occurring amino acid containing selenium. Selenomethionine (SeMet) can substitute for methionine (Met) during protein synthesis in a non-specific manner. Due to the significant differences in their redox properties, the incorporation of SeMet in place of Met may adversely impact protein function. Nov 05 2024
E4598 MEN1703(SEL24,SEL24-B489) MEN1703(SEL24-B489,SEL24, Pim/flt3 kinase inhibitor SEL24) is a potent, type I, orally active, dual inhibitor of PIM and FLT3-ITD, that exhibits Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively. MEN1703 exhibits its broad therapeutic potential in treatment of acute myeloid leukemia. Nov 04 2024
E1841 Monlunabant Monlunabant(INV-202, (S)-MRI-1891) is a peripherally acting inverse agonist of the cannabinoid type-1 receptor (CB1R), with the potential to treat respiratory and renal complications associated with metabolic disorders. It improves lung compliance in a mouse model of asthma and reduces renal fibrosis in a streptozotocin-induced diabetic nephropathy mouse model. Oct 30 2024
E4990 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM TFSI) is a room-temperature ionic liquid with excellent ionic conductivity. Its solvation dynamics and conductivity are affected by proton concentration, which influences its performance in electrochemical applications. Oct 30 2024
S9881 M4205（IDRX-42） M4205 (IDRX-42) is an oral, selective inhibitor of KIT with broad activity against mutations in KIT exons 11, 13, and 17. It exhibits significant and dose-dependent antitumor activity in the xenograft model of GIST. Oct 30 2024
E4940 Chlorphenesin carbamate Chlorphenesin carbamate(Maolate, Rinlaxer, U 19646) is a centrally-acting muscle relaxant that inhibits motoneuron excitability. It is also used to treat pain and discomfort related to skeletal muscle trauma and inflammation. Oct 30 2024
E4924 Anagrelide Anagrelide(BL416201), an imidazoquinazoline derivative, is an inhibitor of phosphodiesterase type III (PDEIII) with IC50 of 36 nM, which acts as an antithrombotic and platelet-reducing agent. Oct 30 2024
E4955 Pitolisant Pitolisant(BF2.649, Tiprolisant) is a potent, selective antagonist of the non-imidazole histamine H3 receptor, with a Ki value of 0.16 nM and an EC50 of 1.5 nM as an inverse agonist. It enhances the activity of histaminergic neurons, promoting vigilance and cognitive function. It is useful in research on wakefulness, memory deficits, and cognitive disorders. Oct 30 2024
E4984 Avibactam free acid Avibactam free acid(NXL-104 free acid) is a potent, covalent, reversible, non–β-lactam Inhibitor of β-lactamase, inhibiting β-lactamase TEM-1 and CTX-M-15 with an IC50 of 8 nM and 5 nM, respectively. It is useful in research on Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium, Gram-negative infections. Oct 30 2024