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Remodelin hydrobromide

Synonyms: Remodelin HBr

Catalog No.S7641 Purity:99.95%

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

Remodelin hydrobromide Chemical Structure

CAS No. 1622921-15-6

Purity & Quality Control

Batch: Purity: 99.95%

99.95

Remodelin hydrobromide Related Products

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Signaling Pathway

Histone Acetyltransferase Signaling Pathway

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
BTI-TN-5B1-4	Function assay	Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay, IC50 = 0.22387 μM.	20579890
BTI-TN-5B1-4	Function assay	Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay, IC50 = 0.22387 μM.	20579890
Click to View More Cell Line Experimental Data

Biological Activity

Description

Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.

Targets

NAT10 ^[1]

In vitro
In vitro	Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. ^[1]
Cell Research	Cell lines	PC-3 and VCaP cells
	Concentrations	20 µM
	Incubation Time	48 h
	Method	Cells were treated with different concentrations of Remodelin (0, 2, 10, 20, or 40 µM) for 48 h and proliferation was evaluated.
Experimental Result Images	Methods	Biomarkers	Images	PMID
Experimental Result Images	Western blot	NAT10 / E-cadherin / Vimentin		31354912

References
[1] Larrieu D, et al. Science. 2014, 344(6183), 527-532. [2] Ma N, et al. Int J Mol Sci. 2022 Jun 12;23(12):6573.

References

Chemical Information & Solubility

Molecular Weight	363.28	Formula	C₁₅H₁₅BrN₄S
CAS No.	1622921-15-6	SDF	Download Remodelin hydrobromide SDF
Smiles	C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1.Br
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 50 mg/mL ( (137.63 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo Batch: Add solvents to the product individually and in order.					In vivo Formulation Calculator
	Clear solution	10% DMSO 1 40% PEG 300 2 5%Tween80 3 45% water	4.0mg/ml (11.01mM)	Taking the 1 mL working solution as an example, add 100 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue adding Dilute 450 μL ddH2O to 1 mL. The mixed solution should be used immediately for optimal results.	In vivo Formulation Calculator
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	2.0mg/ml (5.51mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 Corn oil	2.5mg/ml (6.88mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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