Home Epigenetics Histone Acetyltransferase inhibitor WM-1119 For research use only.

WM-1119

WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.

WM-1119 Chemical Structure

WM-1119 Chemical Structure

CAS No. 2055397-28-7

Purity & Quality Control

Batch: S877601 DMSO]78 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.89%
99.89

WM-1119 Related Products

Signaling Pathway

Histone Acetyltransferase Signaling Pathways

Histone Acetyltransferase Signaling Pathway

Biological Activity

Description WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.
Targets
KAT6A [1]
(Cell-free assay)		 KAT7 [1]
(Cell-free assay)		 KAT5 [1]
(Cell-free assay)
0.002 μM(Kd) 0.5 μM(Kd) 2.2 μM(Kd)
In vitro
In vitro

Treatment of MEFs with WM-1119 resulted in cell cycle arrest in G1 and a senescence phenotype. Treatment with WM-1119 inhibits the proliferation of the EMRK1184 lymphoma cells in vitro. Treatment with WM-1119 results in increased levels of Cdkn2a and Cdkn2b mRNA and p16INK4a and p19ARF proteins, as well as a delayed increase in Cdkn1a mRNA[1].
In Vivo
In vivo

WM-1119 is effective in treating lymphoma in vivo while its treatment has no effect on haematocrit, erythrocytes or platelet numbers, but there was overall leukopenia[1].

Chemical Information & Solubility

Molecular Weight 389.38 Formula

C18H13F2N3O3S
CAS No. 2055397-28-7 SDF --
Smiles C1=CC=C(C(=C1)F)S(=O)(=O)NNC(=O)C2=CC(=CC(=C2)C3=CC=CC=N3)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 78 mg/mL ( (200.31 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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