Home Epigenetics Histone Acetyltransferase inhibitor MG149 For research use only.

MG149

Synonyms: Tip60 HAT inhibitor

MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.

MG149 Chemical Structure

MG149 Chemical Structure

CAS No. 1243583-85-8

Purity & Quality Control

MG149 Related Products

Signaling Pathway

Histone Acetyltransferase Signaling Pathways

Histone Acetyltransferase Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) Function assay 5 mins Inhibition of human MOF expressed in Escherichia coli BL21(DE3) cells using [14C]AC-CoA and histone H4 as substrate after 5 mins by scintillation counting, IC50 = 47 μM. 22100137
SJ-GBM2 qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells 29435139
SK-N-MC qHTS assay qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells 29435139
HCT116 Function assay 100 uM 14 days Inhibition of colony formation in human HCT116 cells at 100 uM after 14 days by crystal violet staining based assay 30145373
Click to View More Cell Line Experimental Data

Biological Activity

Description MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
Targets
MOF [1]
(Cell-free assay)		 Tip60 [1]
(Cell-free assay)
47 μM 74 μM
In vitro
In vitro MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2]
Experimental Result Images Methods Biomarkers Images PMID
Growth inhibition assay Cell viability 28202522

Chemical Information & Solubility

Molecular Weight 340.46 Formula

C22H28O3
CAS No. 1243583-85-8 SDF Download MG149 SDF
Smiles CCCCCCCC1=CC=C(C=C1)CCC2=C(C(=CC=C2)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 68 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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