MG149

Catalog No.S7476 Batch:S747602

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Technical Data

Formula

C22H28O3
Molecular Weight 340.46 CAS No. 1243583-85-8
Solubility (25°C)* In vitro DMSO 68 mg/mL (199.72 mM)
Ethanol 68 mg/mL (199.72 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.56mg/ml Taking the 1 mL working solution as an example, add 50 μL of 11.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.4mg/ml Taking the 1 mL working solution as an example, add 50 μL of 68 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively.
Targets
MOF [1]
(Cell-free assay)		 Tip60 [1]
(Cell-free assay)
47 μM 74 μM
In vitro MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2]

Protocol (from reference)

Selleck's MG149 has been cited by 22 publications

TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release [ Clin Exp Hypertens, 2023, 45(1):2259130] PubMed: 37817460
Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions [ iScience, 2023, 26(12):108446] PubMed: 38034359
The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells [ Int J Mol Sci, 2023, 24(10)8719] PubMed: 37240065
TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription [ Brain Behav Immun, 2022, S0889-1591(22)00025-3] PubMed: 35114329
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling [ Nucleic Acids Res, 2022, 50(15):8700-8718] PubMed: 35904816
Attenuation of histone H4 lysine 16 acetylation (H4K16ac) elicits a neuroprotection against ischemic stroke by alleviating the autophagic/lysosomal dysfunction in neurons at the penumbra [ Brain Res Bull, 2022, 184:24-33] PubMed: 35351588
Inhibition of Rice SerotoninN-Acetyltransferases by MG149 Decreased Melatonin Synthesis in Rice Seedlings [ Biomolecules-, 2021, 11(5), 658] PubMed: None
Inhibition of Rice Serotonin N-Acetyltransferases by MG149 Decreased Melatonin Synthesis in Rice Seedlings [ Biomolecules, 2021, 11(5)658] PubMed: 33946959
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells [ Mol Cell Endocrinol, 2021, 537:111425] PubMed: 34391847
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling [ bioRxiv, 2021, 2021.04.21.440833] PubMed: 33907746

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.