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Technical Data
| Formula | C22H28O3 |
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| Molecular Weight | 340.46 | CAS No. | 1243583-85-8 | |
| Solubility (25°C)* | In vitro | DMSO | 68 mg/mL (199.72 mM) | |
| Ethanol | 68 mg/mL (199.72 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | MG149 (Tip60 HAT inhibitor) is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively. | ||||
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| Targets |
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| In vitro | MG149 targets the acetyl-CoA binding site, and inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. [1] MG149 also inhibits the p53 and the NF-κB pathways. [2] |
Protocol (from reference)
References
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Selleck's MG149 has been cited by 23 publications
| Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells [ Int J Mol Sci, 2024, 25(17)9600] | PubMed: 39273544 |
| TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release [ Clin Exp Hypertens, 2023, 45(1):2259130] | PubMed: 37817460 |
| Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions [ iScience, 2023, 26(12):108446] | PubMed: 38034359 |
| The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells [ Int J Mol Sci, 2023, 24(10)8719] | PubMed: 37240065 |
| TIP60 buffers acute stress response and depressive behaviour by controlling PPARγ-mediated transcription [ Brain Behav Immun, 2022, S0889-1591(22)00025-3] | PubMed: 35114329 |
| FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling [ Nucleic Acids Res, 2022, 50(15):8700-8718] | PubMed: 35904816 |
| Attenuation of histone H4 lysine 16 acetylation (H4K16ac) elicits a neuroprotection against ischemic stroke by alleviating the autophagic/lysosomal dysfunction in neurons at the penumbra [ Brain Res Bull, 2022, 184:24-33] | PubMed: 35351588 |
| Inhibition of Rice SerotoninN-Acetyltransferases by MG149 Decreased Melatonin Synthesis in Rice Seedlings [ Biomolecules-, 2021, 11(5), 658] | PubMed: None |
| Inhibition of Rice Serotonin N-Acetyltransferases by MG149 Decreased Melatonin Synthesis in Rice Seedlings [ Biomolecules, 2021, 11(5)658] | PubMed: 33946959 |
| Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells [ Mol Cell Endocrinol, 2021, 537:111425] | PubMed: 34391847 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.