Remodelin hydrobromide

Catalog No.S7641 Batch:S764102

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Technical Data

Formula

C15H15BrN4S
Molecular Weight 363.28 CAS No. 1622921-15-6
Solubility (25°C)* In vitro DMSO 50 mg/mL (137.63 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
10% DMSO 40% PEG 300 5%Tween80 45% water
4.0mg/ml Taking the 1 mL working solution as an example, add 100 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue adding Dilute 450 μL ddH2O to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Remodelin hydrobromide (HBr) is a potent acetyl-transferase NAT10 inhibitor.
Targets
NAT10 [1]
In vitro

Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases. [1]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    PC-3 and VCaP cells

  • Concentrations

    20 µM

  • Incubation Time

    48 h

  • Method

    Cells were treated with different concentrations of Remodelin (0, 2, 10, 20, or 40 µM) for 48 h and proliferation was evaluated.

Selleck's Remodelin hydrobromide has been cited by 19 publications

N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration [ Nat Commun, 2024, 15(1):2137] PubMed: 38459019
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury [ Redox Biol, 2024, 72:103145] PubMed: 38583415
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway [ J Adv Res, 2024, S2090-1232(24)00318-7] PubMed: 39089619
Targeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy [ Mol Med, 2024, 30(1):13] PubMed: 38243170
Targeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy [ Mol Med, 2024, 30(1):13] PubMed: 38243170
Remodelin delays non-small cell lung cancer progression by inhibiting NAT10 via the EMT pathway [ Cancer Med, 2024, 13(11):e7283] PubMed: 38826095
N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop [ Adv Sci (Weinh), 2023, 10(23):e2300898] PubMed: 37328448
Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression [ J Exp Clin Cancer Res, 2023, 42(1):9] PubMed: 36609449
P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma [ Mol Cell Proteomics, 2023, 22(3):100504] PubMed: 36708875
Inhibition of N-Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication [ Int J Mol Sci, 2022, 23(12)6573] PubMed: 35743017

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.