HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7913 LY 303511 hydrochloride LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells. Dec 20 2024
S9717 Vecabrutinib Vecabrutinib (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib shows an IC50 of 24 nM for ITK. Dec 20 2024
E7658 Fluxametamide Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls. Dec 20 2024
E7914 Desisobutyryl-ciclesonide Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor. Dec 20 2024
E1172 Dynarrestin Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. Dec 20 2024
E7659 RO-28-1675 RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes. Dec 20 2024
E7915 9-Deazaguanine 9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP). Dec 20 2024
E8144 PIM447 PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis. Dec 20 2024
E7660 Neurotensin Neurotensin is a 13-amino acid neuropeptide present in the central nervous system and gastrointestinal tract. It acts as a potent mitogen for colorectal and pancreatic cancers with high-affinity NT receptors (NTR) and can be used in the treatment of diseases such as schizophrenia, Parkinson's disease and addiction. Dec 20 2024
E7916 FTY720 (S)-Phosphate FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. Dec 20 2024
E5776 Asymmetric dimethylarginine Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Dec 20 2024
E7661 CDK9-IN-1 CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. Dec 20 2024
E7917 Ro 90-7501 Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells. Dec 20 2024
S7822 Kifunensine Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD. Dec 20 2024
E7662 α-Lipoic acid-NHS α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Dec 20 2024
E7918 Obovatol Obovatol is a biphenyl ether lignan isolated from the leaves of Magnolia obovata Thunb. Dec 20 2024
E1317 LY 345899 LY345899 is a Folate analog and a potent inbhibitor of methylene tetrahydrofolate dehydrogenase1 (MTHFD1; DC301) and methylene tetrahydrofolate dehydrogenase2 (MTHFD2) with IC50 values of 96 nM and 663 nM, respectively. It significantly suppresses tumor growth and reduces tumor weight in CRC patient-derived xenograft models. Dec 20 2024
E7663 O-1602 O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1. Dec 20 2024
E7919 (±)-Ibipinabant (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM. Dec 20 2024
E1765 U-73343 U-73343 is an inactive analog of U-73122 that acts downstream of phospholipase C and inhibits receptor-mediated phospholipase D (PLD) activation in CHO-CCK_A cells. Dec 20 2024