Home GPCR & G Protein Adrenergic Receptor agonist - eIF inhibitor Guanabenz hydrochloride For research use only.

Guanabenz hydrochloride

Synonyms: NE56490

Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.

Guanabenz hydrochloride Chemical Structure

Guanabenz hydrochloride Chemical Structure

CAS No. 23113-43-1

Purity & Quality Control

Batch: E488801 DMSO]54 mg/mL]false]Water]13 mg/mL]false]Ethanol]13 mg/mL]false Purity: 99.93%
99.93

Guanabenz hydrochloride Related Products

Signaling Pathway

Adrenergic Receptor Signaling Pathways

Adrenergic Receptor Signaling Pathway

Biological Activity

Description Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.
Targets
α2-adrenoceptor [1] eIF2α [1]

Chemical Information & Solubility

Molecular Weight 267.54 Formula

C8H8Cl2N4.ClH
CAS No. 23113-43-1 SDF Download Guanabenz hydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (201.83 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 13 mg/mL

Ethanol : 13 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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