Home Methylation DNA Methyltransferase inhibitor GSK-3484862 For research use only.

GSK-3484862

GSK-3484862 is a non-covalent, potent and selective inhibitor of DNMT1 with an IC50 of 0.23 μM. It demonstrates efficacy in acute myeloid leukemia.

GSK-3484862 Chemical Structure

GSK-3484862 Chemical Structure

CAS No. 2170136-65-7

Purity & Quality Control

Batch: E155601 DMSO]24 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.58%
99.58

GSK-3484862 Related Products

Signaling Pathway

DNA Methyltransferase Signaling Pathways

DNA Methyltransferase Signaling Pathway

Biological Activity

Description GSK-3484862 is a non-covalent, potent and selective inhibitor of DNMT1 with an IC50 of 0.23 μM. It demonstrates efficacy in acute myeloid leukemia.
Targets
DNMT1 [1]
0.23 μM

Chemical Information & Solubility

Molecular Weight 365.45 Formula

C19H19N5OS
CAS No. 2170136-65-7 SDF Download GSK-3484862 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 24 mg/mL ( (65.67 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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