Home Metabolism PDE chemical OPB-171775 For research use only.

OPB-171775

OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST).

OPB-171775 Chemical Structure

OPB-171775 Chemical Structure

CAS No. 2131210-15-4

Purity & Quality Control

Batch: E469501 DMSO]62 mg/mL]false]Ethanol]62 mg/mL]false]Water]Insoluble]false Purity: 97.78%
97.78

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Biological Activity

Description OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST).

Chemical Information & Solubility

Molecular Weight 312.31 Formula

C15H18F2N2O3
CAS No. 2131210-15-4 SDF Download OPB-171775 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (198.52 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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