Home Metabolism Dehydrogenase inhibitor Isovaleramide For research use only.

Isovaleramide

Synonyms: 3-Methylbutanamide

Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.

Isovaleramide Chemical Structure

Isovaleramide Chemical Structure

CAS No. 541-46-8

Purity & Quality Control

Isovaleramide Related Products

Signaling Pathway

Dehydrogenase Signaling Pathways

Dehydrogenase Signaling Pathway

Biological Activity

Description Isovaleramide(3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.
Targets
alcohol dehydrogenase [4]
In vitro
In vitro

Isovaleramide is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. [1] Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. [2] Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. [3]
In Vivo
In vivo

Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). [1] Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits. [2]

Chemical Information & Solubility

Molecular Weight 101.15 Formula

C5H11NO
CAS No. 541-46-8 SDF Download Isovaleramide SDF
Smiles CC(C)CC(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 20 mg/mL ( (197.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 20 mg/mL

Ethanol : 20 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Isovaleramide | Isovaleramide supplier | purchase Isovaleramide | Isovaleramide cost | Isovaleramide manufacturer | order Isovaleramide | Isovaleramide distributor