Home Metabolism Dehydrogenase inhibitor AG-120 (racemic) For research use only.

AG-120 (racemic)

AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.

AG-120 (racemic) Chemical Structure

AG-120 (racemic) Chemical Structure

CAS No. 1448346-63-1

Purity & Quality Control

AG-120 (racemic) Related Products

Signaling Pathway

Dehydrogenase Signaling Pathways

Dehydrogenase Signaling Pathway

Biological Activity

Description AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
Targets
IDH1 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03343197 Active not recruiting
Glioma
Institut de Recherches Internationales Servier|Servier
 March 20 2018 Phase 1
NCT03173248 Active not recruiting
Newly Diagnosed Acute Myeloid Leukemia (AML)|Untreated AML|AML Arising From Myelodysplastic Syndrome (MDS)|Leukemia Myeloid Acute
Institut de Recherches Internationales Servier|Servier
 June 26 2017 Phase 3
NCT02989857 Completed
Advanced Cholangiocarcinoma|Metastatic Cholangiocarcinoma
Institut de Recherches Internationales Servier|Servier
 February 20 2017 Phase 3
NCT02831972 Completed
Healthy
Agios Pharmaceuticals Inc.
 June 2016 Phase 1
NCT02489513 Completed
Healthy Volunteers
Agios Pharmaceuticals Inc.
 June 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 582.96 Formula

C28H22ClF3N6O3
CAS No. 1448346-63-1 SDF --
Smiles C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (171.53 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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