Home Metabolism Dehydrogenase inhibitor Brequinar Sodium For research use only.

Brequinar Sodium

Synonyms: Bipenquinate, BRQ, DUP-785, NSC 368390

Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.

Brequinar Sodium Chemical Structure

Brequinar Sodium Chemical Structure

CAS No. 96201-88-6

Purity & Quality Control

Brequinar Sodium Related Products

Signaling Pathway

Dehydrogenase Signaling Pathways

Dehydrogenase Signaling Pathway

Biological Activity

Description Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.
Targets
DHODH [1]
(Cell-free assay)
20 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05945251 Recruiting
Functional Abdominal Pain Syndrome
Karolinska Institutet|Child and Adolescent Psychiatry Stockholm
 November 1 2023 --
NCT04294420 Completed
Functional Gastrointestinal Disorders
Karolinska Institutet
 May 1 2020 Not Applicable
NCT03252743 Completed
Functional Gastrointestinal Disorders|Irritable Bowel Syndrome|Dyspepsia|Functional Abdominal Pain
Karolinska Institutet
 September 1 2017 Not Applicable
NCT02873078 Completed
Functional Abdominal Pain Disorders
Karolinska Institutet
 August 2016 Not Applicable
NCT02475096 Completed
Functional Gastrointestinal Disorders
Karolinska Institutet
 July 2015 Not Applicable

Chemical Information & Solubility

Molecular Weight 397.35 Formula

C23H14F2NNaO2
CAS No. 96201-88-6 SDF --
Smiles CC1=C(C(=O)O[Na])C2=CC(=CC=C2N=C1C3=CC=C(C=C3)C4=C(F)C=CC=C4)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 79 mg/mL ( (198.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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