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Transferase Inhibitors (39)
New Transferase Products

Catalog No.	Product Name	Information	Product Use Citations
S2799	Daporinad (FK866)	Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.	Cell Discov, 2024, 10(1):39 Theranostics, 2024, 14(7):2794-2815 Theranostics, 2024, 14(15):5999-6015
S8244	Etomoxir sodium salt	Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.	Bioact Mater, 2024, 35:549-563 Cell Chem Biol, 2024, 31(10):1772-1786.e5 Oncogene, 2024, 43(6):406-419
S1453	Tipifarnib	Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.	Cell Rep, 2023, 42(9):113098 iScience, 2023, 26(5):106695 Int J Mol Sci, 2023, 24(14)11546
S2797	Lonafarnib (SCH66336)	Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.	J Cell Biol, 2024, 223(1)e202303007 J Cell Biol, 2024, 223(1)e202303007 EMBO Rep, 2024, 25(10):4311-4336
S7465	FTI 277 HCl	FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.	Cancer Res, 2023, 83(13):2248-2261 PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9
S7466	GGTI 298 TFA salt	GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.	bioRxiv, 2024, 10.1101/2024.01.16.575899 Nat Commun, 2023, 14(1):3251 Cell Struct Funct, 2021, 46(1):1-9
S4989	AOA (Aminooxyacetic acid) hemihydrochloride	AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.	Research Square, 2024, 10.21203/rs.3.rs-3849836/v1 Cell Rep Med, 2023, 4(5):101026 EMBO Mol Med, 2023, e15674.
S8608	ADOX (Adenosine Dialdehyde)	ADOX (Adenosine Dialdehyde) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.	Nat Commun, 2024, 15(1):8971 EMBO J, 2023, e114558. PLoS Biol, 2022, 20(2):e3001535
S3021	Rimonabant (SR141716)	Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.	Toxicol Lett, 2023, 374:48-56 Int J Biol Sci, 2022, 18(4):1401-1414 Mol Metab, 2022, 65:101597
S9870	STM2457	STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.	Nat Commun, 2024, 15(1):8539 Cell Rep, 2024, 43(2):113796 Cell Mol Biol Lett, 2024, 29(1):106
S7894	Tunicamycin	Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis.	Cell Discov, 2023, 9(1):92 Cell Discov, 2023, 9(1):92 Adv Sci (Weinh), 2023, 10(25):e2300414
S4589	Amodiaquine dihydrochloride dihydrate	Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.	Cell Death Differ, 2023, 10.1038/s41418-023-01167-4 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9 J Med Chem, 2020, 31
S8910	OSMI-4	OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.	Elife, 2023, 12e85595 Sci Adv, 2023, 9(33):eadg7112 Sci Adv, 2023, 9(33):eadg7112
S2674	A922500	A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.	Nature, 2023, 621(7977):171-178 Nature, 2023, 621(7977):171-178 Cell Rep, 2022, 41(11):111827
S4021	Tolcapone	Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.	FASEB J, 2022, 36(7):e22399 Viruses, 2021, 13(8)1533 Front Bioinform, 2021, 1:710591
S4743	Wogonin	Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.	Cancers -Basel, 2022, 14-174200 J Surg Res, 2021, 263:236-244 Exp Ther Med, 2015, 10(3):1066-1070
E0081	FIDAS-3	FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.	Cell Death Dis, 2023, 14(8):525 Cell Death Dis, 2023, 14(8):525
S9954	SGN-2FF	SGN‐2FF (2-fluorofucose) is an orally bioavailable small‐molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models.	Aging Dis, 2023, 14(5):1927-1944 Aging Dis, 2023, 14(5):1927-1944
S7192	PF-04620110	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.	J Pharm Biomed Anal, 2019, 170:176-186 J Cell Biol, 2018, 217(3):975-995
E1017	ERG240	ERG240, a selective inhibitor of branched-chain aminotransferase 1 (BCAT1) with an IC50 of 0.1-1nM, leads to decreased oxygen consumption and glycolysis through the down regulation of IRG1 expression, which leads to decrease itaconate production in human macrophages.	Adv Sci (Weinh), 2023, 10(13):e2206439
E0120	2-BP (2-Bromohexadecanoic acid)	2-BP (2-Bromohexadecanoic acid) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor, which inhibits multiple palmitoyl-acyl transferase (PAT) activity towards MyrGCK(NBD) and FarnCNRas(NBD) with identical IC50s of approx. 4 µM. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins.	Cell Mol Biol Lett, 2024, 29(1):112 J Virol, 2024, 98(4):e0164923 Cancer Res, 2023, 83(12):2034-2051
S9835	OSMI-1	OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 μM for full length human OGT (ncOGT).	Cell Death Dis, 2024, 15(4):244 Biomed Res Int, 2020, 2020:1921609
S2994	DL-Homocysteine	DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.
E1029	Miglustat	Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside.
S9231	Schisanhenol	Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.	Exploratory Research and Hypothesis in Medicine, 2023, 10.14218/ERHM.2023.00054
S0970	Curzerene	Curzerene, a sesquiterpene isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity, inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression and induces cell apoptosis.
S9698	Ezatiostat	Ezatiostat, a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.
S5336	Hecogenin	Hecogenin (Hocogenin), a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM.
S3945	L-Cycloserine	L-Cycloserine (Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.
E0405	L002 (NSC764414)	L002 (NSC764414) is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM.
S5449	3-Methoxybenzamide	3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)
S0359	T863 (DGAT-3)	T863 (DGAT-3) is a potent, selective and orally active inhibitor of Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) tht acts on the acyl-CoA binding site of DGAT1 and inhibits DGAT1-mediated triacylglycerol formation in cells.
E4639^New	FIDAS-5	FIDAS-5 is a potent and orally active inhibitor of methionine S-adenosyltransferase 2A (MAT2A) with an IC50 value of 2.1 μM, respectively. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 also demonstrates anticancer activity.
S4189	Cyclandelate	Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
S7467	LB42708	LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.	Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221
S5166	Benzoyleneurea	Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
S6886	1-Aminobenzotriazole	1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
S4280	Meclofenoxate (Centrophenoxine) HCl	Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
S6392^New	SHIN1(RZ-2994)	SHIN1 (RZ-2994) is an inhibitor of SHMT1/2 (human serine hydroxymethyltransferase 1 and 2) with IC50 values of 5 and 13 nM, respectively, in in vitro assay. SHIN1 hinders cell growth by gradually reducing purine levels.
S2799	Daporinad (FK866)	Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. Daporinad (FK866, APO866) triggers autophagy. Phase 1/2.	Cell Discov, 2024, 10(1):39 Theranostics, 2024, 14(7):2794-2815 Theranostics, 2024, 14(15):5999-6015
S8244	Etomoxir sodium salt	Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.	Bioact Mater, 2024, 35:549-563 Cell Chem Biol, 2024, 31(10):1772-1786.e5 Oncogene, 2024, 43(6):406-419
S1453	Tipifarnib	Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.	Cell Rep, 2023, 42(9):113098 iScience, 2023, 26(5):106695 Int J Mol Sci, 2023, 24(14)11546
S2797	Lonafarnib (SCH66336)	Lonafarnib (SCH66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.	J Cell Biol, 2024, 223(1)e202303007 J Cell Biol, 2024, 223(1)e202303007 EMBO Rep, 2024, 25(10):4311-4336
S7465	FTI 277 HCl	FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.	Cancer Res, 2023, 83(13):2248-2261 PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9
S7466	GGTI 298 TFA salt	GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.	bioRxiv, 2024, 10.1101/2024.01.16.575899 Nat Commun, 2023, 14(1):3251 Cell Struct Funct, 2021, 46(1):1-9
S4989	AOA (Aminooxyacetic acid) hemihydrochloride	AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.	Research Square, 2024, 10.21203/rs.3.rs-3849836/v1 Cell Rep Med, 2023, 4(5):101026 EMBO Mol Med, 2023, e15674.
S8608	ADOX (Adenosine Dialdehyde)	ADOX (Adenosine Dialdehyde) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.	Nat Commun, 2024, 15(1):8971 EMBO J, 2023, e114558. PLoS Biol, 2022, 20(2):e3001535
S3021	Rimonabant (SR141716)	Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.	Toxicol Lett, 2023, 374:48-56 Int J Biol Sci, 2022, 18(4):1401-1414 Mol Metab, 2022, 65:101597
S9870	STM2457	STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.	Nat Commun, 2024, 15(1):8539 Cell Rep, 2024, 43(2):113796 Cell Mol Biol Lett, 2024, 29(1):106
S7894	Tunicamycin	Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis.	Cell Discov, 2023, 9(1):92 Cell Discov, 2023, 9(1):92 Adv Sci (Weinh), 2023, 10(25):e2300414
S4589	Amodiaquine dihydrochloride dihydrate	Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.	Cell Death Differ, 2023, 10.1038/s41418-023-01167-4 Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9 J Med Chem, 2020, 31
S8910	OSMI-4	OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.	Elife, 2023, 12e85595 Sci Adv, 2023, 9(33):eadg7112 Sci Adv, 2023, 9(33):eadg7112
S2674	A922500	A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.	Nature, 2023, 621(7977):171-178 Nature, 2023, 621(7977):171-178 Cell Rep, 2022, 41(11):111827
S4021	Tolcapone	Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.	FASEB J, 2022, 36(7):e22399 Viruses, 2021, 13(8)1533 Front Bioinform, 2021, 1:710591
S4743	Wogonin	Wogonin (Vogonin), a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.	Cancers -Basel, 2022, 14-174200 J Surg Res, 2021, 263:236-244 Exp Ther Med, 2015, 10(3):1066-1070
E0081	FIDAS-3	FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.	Cell Death Dis, 2023, 14(8):525 Cell Death Dis, 2023, 14(8):525
S9954	SGN-2FF	SGN‐2FF (2-fluorofucose) is an orally bioavailable small‐molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models.	Aging Dis, 2023, 14(5):1927-1944 Aging Dis, 2023, 14(5):1927-1944
S7192	PF-04620110	PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.	J Pharm Biomed Anal, 2019, 170:176-186 J Cell Biol, 2018, 217(3):975-995
E1017	ERG240	ERG240, a selective inhibitor of branched-chain aminotransferase 1 (BCAT1) with an IC50 of 0.1-1nM, leads to decreased oxygen consumption and glycolysis through the down regulation of IRG1 expression, which leads to decrease itaconate production in human macrophages.	Adv Sci (Weinh), 2023, 10(13):e2206439
E0120	2-BP (2-Bromohexadecanoic acid)	2-BP (2-Bromohexadecanoic acid) is a nonmetabolisable analogue of palmitate and acts as a palmitoylation inhibitor, which inhibits multiple palmitoyl-acyl transferase (PAT) activity towards MyrGCK(NBD) and FarnCNRas(NBD) with identical IC50s of approx. 4 µM. 2-Bromohexadecanoic acid can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins.	Cell Mol Biol Lett, 2024, 29(1):112 J Virol, 2024, 98(4):e0164923 Cancer Res, 2023, 83(12):2034-2051
S9835	OSMI-1	OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 μM for full length human OGT (ncOGT).	Cell Death Dis, 2024, 15(4):244 Biomed Res Int, 2020, 2020:1921609
S2994	DL-Homocysteine	DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.
E1029	Miglustat	Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside.
S9231	Schisanhenol	Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.	Exploratory Research and Hypothesis in Medicine, 2023, 10.14218/ERHM.2023.00054
S0970	Curzerene	Curzerene, a sesquiterpene isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity, inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression and induces cell apoptosis.
S9698	Ezatiostat	Ezatiostat, a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.
S5336	Hecogenin	Hecogenin (Hocogenin), a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM.
S3945	L-Cycloserine	L-Cycloserine (Levcycloserine, Levcicloserina, Levcycloserinum, (-)-Cycloserine, (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.
E0405	L002 (NSC764414)	L002 (NSC764414) is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM.
S5449	3-Methoxybenzamide	3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)
S0359	T863 (DGAT-3)	T863 (DGAT-3) is a potent, selective and orally active inhibitor of Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) tht acts on the acyl-CoA binding site of DGAT1 and inhibits DGAT1-mediated triacylglycerol formation in cells.
E4639^New	FIDAS-5	FIDAS-5 is a potent and orally active inhibitor of methionine S-adenosyltransferase 2A (MAT2A) with an IC50 value of 2.1 μM, respectively. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 also demonstrates anticancer activity.
S4189	Cyclandelate	Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
S7467	LB42708	LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.	Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221
S5166	Benzoyleneurea	Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
S6886	1-Aminobenzotriazole	1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
S4280	Meclofenoxate (Centrophenoxine) HCl	Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.
S6392^New	SHIN1(RZ-2994)	SHIN1 (RZ-2994) is an inhibitor of SHMT1/2 (human serine hydroxymethyltransferase 1 and 2) with IC50 values of 5 and 13 nM, respectively, in in vitro assay. SHIN1 hinders cell growth by gradually reducing purine levels.
E4639^New	FIDAS-5	FIDAS-5 is a potent and orally active inhibitor of methionine S-adenosyltransferase 2A (MAT2A) with an IC50 value of 2.1 μM, respectively. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 also demonstrates anticancer activity.
S6392^New	SHIN1(RZ-2994)	SHIN1 (RZ-2994) is an inhibitor of SHMT1/2 (human serine hydroxymethyltransferase 1 and 2) with IC50 values of 5 and 13 nM, respectively, in in vitro assay. SHIN1 hinders cell growth by gradually reducing purine levels.

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