Home Epigenetics Histone Methyltransferase inhibitor - Transferase inhibitor - HNMT inhibitor Amodiaquine dihydrochloride dihydrate For research use only.

Amodiaquine dihydrochloride dihydrate

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

Amodiaquine dihydrochloride dihydrate Chemical Structure

Amodiaquine dihydrochloride dihydrate Chemical Structure

CAS No. 6398-98-7

Purity & Quality Control

Amodiaquine dihydrochloride dihydrate Related Products

Signaling Pathway

Histone Methyltransferase Signaling Pathways

Histone Methyltransferase Signaling Pathway

Biological Activity

Description Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
Targets
histamine N-methyl transferase [2]
(Cell-free assay)
18.6 nM(Ki)
In Vivo
In vivo In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1].
Animal Research Animal Models C57BL/6 mice
Dosages 2 and 5 mg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 464.81 Formula

C20H22ClN3O.2HCl.2H2O
CAS No. 6398-98-7 SDF Download Amodiaquine dihydrochloride dihydrate SDF
Smiles CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.O.O.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (197.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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