Amodiaquine dihydrochloride dihydrate

Catalog No.S4589 Batch:S458902

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Technical Data

Formula

C20H22ClN3O.2HCl.2H2O
Molecular Weight 464.81 CAS No. 6398-98-7
Solubility (25°C)* In vitro DMSO 92 mg/mL (197.93 mM)
Water 92 mg/mL (197.93 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
Targets
histamine N-methyl transferase [2]
(Cell-free assay)
18.6 nM(Ki)
In vivo In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1].

Protocol (from reference)

Animal Study:[1]
  • Animal Models

    C57BL/6 mice

  • Dosages

    2 and 5 mg/kg

  • Administration

    s.c.

Selleck's Amodiaquine dihydrochloride dihydrate has been cited by 5 publications

Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET [ Cell Death Differ, 2023, 10.1038/s41418-023-01167-4] PubMed: 37142656
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics [ Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9] PubMed: 33941899
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model [ J Med Chem, 2020, 31] PubMed: 32191458
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics [ bioRxiv, 2020, 10.1101/2020.04.13.039917] PubMed: N/A
Reversal of Infected Host Gene Expression Identifies Repurposed Drug Candidates for COVID-19 [ bioRxiv, 2020, 2020/9/20.4.7.30734] PubMed: 32511305

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.