Home Metabolism P450 (e.g. CYP17) inhibitor - Histone Acetyltransferase inhibitor - Transferase inhibitor 1-Aminobenzotriazole For research use only.

1-Aminobenzotriazole

Synonyms: ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

1-Aminobenzotriazole Chemical Structure

1-Aminobenzotriazole Chemical Structure

CAS No. 1614-12-6

Purity & Quality Control

Batch: S688601 DMSO]27 mg/mL]false]Water]27 mg/mL]false]Ethanol]27 mg/mL]false Purity: 99.99%
99.99

1-Aminobenzotriazole Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
Targets
P450 [1] NAT [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06399536 Not yet recruiting
Transfusion Related Complication|Hemodilution
West China Hospital
 June 1 2024 Not Applicable
NCT05532696 Recruiting
Advanced Solid Tumor|Non Small Cell Lung Cancer|HER2 Mutations
Anbogen Therapeutics Inc.
 September 27 2022 Phase 1|Phase 2
NCT05449249 Completed
Healthy|Periodontitis
Buchinger Wilhelmi Development & Holding GmbH|Buchinger Wilhelmi Clinic|University of Geneva Switzerland|King''s College London|ETH Zurich (Switzerland)
 September 1 2022 Not Applicable
NCT06108869 Suspended
Chronic Spontaneous Urticaria
Royal College of Surgeons Ireland
 June 1 2022 Not Applicable
NCT04053569 Unknown status
Metabolic Syndrome Protection Against
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
 October 1 2019 Not Applicable
NCT04006353 Completed
Drug Interaction
Shanghai Public Health Clinical Center
 July 11 2019 Phase 4

Chemical Information & Solubility

Molecular Weight 134.14 Formula
C6H6N4
CAS No. 1614-12-6 SDF --
Smiles N[N]1N=NC2=CC=CC=C12
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 27 mg/mL ( (201.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 27 mg/mL

Ethanol : 27 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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