Home Metabolism P450 (e.g. CYP17) inhibitor - PREP inhibitor Baicalein For research use only.

Baicalein

Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.

Baicalein Chemical Structure

Baicalein Chemical Structure

CAS No. 491-67-8

Purity & Quality Control

Baicalein Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
Targets
CYP2C9 [1]
In vitro
In vitro

Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).[2]
Cell Research Cell lines Neonatal rat ventricular myocytes (NRVMs)
Concentrations 10 μM
Incubation Time 48 h
Method

Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).
In Vivo
In vivo

Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.[3]
Animal Research Animal Models Nlrp3-/- (021302) mice, Gsdmd-/- (032410) mice, C57BL/6J WT mice
Dosages 30 mg/kg
Administration --

Chemical Information & Solubility

Molecular Weight 270.24 Formula

C15H10O5

CAS No. 491-67-8 SDF Download Baicalein SDF
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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