Baicalein

Catalog No.S2268 Batch:S226802

Technical Data

Formula	C₁₅H₁₀O₅
Molecular Weight	270.24	CAS No.	491-67-8
Solubility (25°C)*	In vitro	DMSO	54 mg/mL (199.82 mM)
		Ethanol	5 mg/mL (18.5 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.

Targets

CYP2C9 ^[1]

In vitro

Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).^[2]

In vivo

Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.^[3]

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines Neonatal rat ventricular myocytes (NRVMs) Concentrations 10 μM Incubation Time 48 h Method Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).
Animal Study:^{^[3]}	Animal Models Nlrp3^-/- (021302) mice, Gsdmd^-/- (032410) mice, C57BL/6J WT mice Dosages 30 mg/kg Administration --

Cell Assay:^{^[2]}

Cell lines
Neonatal rat ventricular myocytes (NRVMs)
Concentrations
10 μM
Incubation Time
48 h
Method
Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).

Animal Study:^{^[3]}

Animal Models
Nlrp3^-/- (021302) mice, Gsdmd^-/- (032410) mice, C57BL/6J WT mice
Dosages
30 mg/kg
Administration
--

References

Customer Product Validation

: , , Mol Cell Biochem, 2015, 406:111–119.

: , , Biochem Biophys Res Commun, 2016, 473(4):775-80.

: Data from [Data independently produced by , , Chem Biol Interact, 2018, 285:48-58]

: Data from [Data independently produced by , , Int J Biochem Cell Biol, 2018, 94:107-118]

Selleck's Baicalein has been cited by 30 publications

Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8]	PubMed: 38301954
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis [ Redox Rep, 2023, 28(1):2152607]	PubMed: 36692085
Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline [ Microbiol Spectr, 2023, 11(3):e0470222]	PubMed: 37070985
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [ J Transl Int Med, 2023, 11(2):178-188]	PubMed: 37408574
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9]	PubMed: 35868306
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation [ Pharmacol Res, 2022, 185:106489]	PubMed: 36228869
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies [ Int J Biol Macromol, 2022, S0141-8130(22)02224-3]	PubMed: 36252624
奥曲肽联合黄芩素抑制胰腺神经内分泌肿瘤细胞增殖和迁移. [ Progress in Modern Biomedicine, 2022, Vol.22]	PubMed: none
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360]	PubMed: 34918496
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins [ Free Radic Biol Med, 2021, 163:234-242]	PubMed: 33359684

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.