Home Metabolism P450 (e.g. CYP17) chemical Amentoflavone For research use only.

Amentoflavone

Synonyms: Didemethyl Ginkgetin

Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.

Amentoflavone Chemical Structure

Amentoflavone Chemical Structure

CAS No. 1617-53-4

Purity & Quality Control

Amentoflavone Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Biological Activity

Description Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
In vitro
In vitro Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1].
Cell Research Cell lines MCF-7 cells
Concentrations 250 μM
Incubation Time 6-72 h
Method Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone, or with vehicle (DMSO, 0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes, cells are photographed under a phase-contrast microscope.
In Vivo
In vivo In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons[2].
Animal Research Animal Models Kunming mice
Dosages 25 mg/kg
Administration intragastrically administered

Chemical Information & Solubility

Molecular Weight 538.46 Formula

C30H18O10
CAS No. 1617-53-4 SDF Download Amentoflavone SDF
Smiles C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (185.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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