Amentoflavone

Catalog No.S3833 Batch:S383301

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Technical Data

Formula

C30H18O10
Molecular Weight 538.46 CAS No. 1617-53-4
Solubility (25°C)* In vitro DMSO 100 mg/mL (185.71 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
In vitro Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1].
In vivo In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons[2].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    MCF-7 cells

  • Concentrations

    250 μM

  • Incubation Time

    6-72 h

  • Method

    Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone, or with vehicle (DMSO, 0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes, cells are photographed under a phase-contrast microscope.

Animal Study:[2]
  • Animal Models

    Kunming mice

  • Dosages

    25 mg/kg

  • Administration

    intragastrically administered

Selleck's Amentoflavone has been cited by 2 publications

New Insights on Structures Forming the Lignin-Like Fractions of Ancestral Plants [ Front Plant Sci, 2021, 12:740923] PubMed: 34691117
Amentoflavone Inhibits HSV-1 and ACV-Resistant Strain Infection by Suppressing Viral Early Infection [ Viruses, 2019, 11(5)E466] PubMed: 31121928

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.