Piperine

Synonyms: 1-Piperoylpiperidine

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.

Piperine Chemical Structure

Piperine Chemical Structure

CAS No. 94-62-2

Purity & Quality Control

Piperine Related Products

Biological Activity

Description Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
Targets
CYP3A4 [1]
In vitro
In vitro Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. [1] Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor. [2]
In Vivo
In vivo LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.) [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05542394 Completed
Plasma Levels of Different Curcuminoids Preparations
University of Jordan|Nutritional Fundamentals for Health
September 20 2022 Not Applicable
NCT04731844 Recruiting
Prostate Cancer|Multiple Myeloma|Smoldering Multiple Myeloma (SMM)|Monoclonal Gammopathy of Undetermined Significance
University of Rochester
December 14 2021 Phase 2
NCT00181662 Completed
Healthy
Massachusetts General Hospital
August 2005 Not Applicable

Chemical Information & Solubility

Molecular Weight 285.34 Formula

C17H19NO3

CAS No. 94-62-2 SDF Download Piperine SDF
Smiles C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 57 mg/mL ( (199.76 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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