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Formula | C15H10O5 |
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Molecular Weight | 270.24 | CAS No. | 491-67-8 | |
Solubility (25°C)* | In vitro | DMSO | 54 mg/mL (199.82 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. | |
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Targets |
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In vitro | Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).[2] |
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In vivo | Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.[3] |
Cell Assay: |
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Animal Study: |
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, , Mol Cell Biochem, 2015, 406:111–119.
, , Biochem Biophys Res Commun, 2016, 473(4):775-80.
Data from [Data independently produced by , , Chem Biol Interact, 2018, 285:48-58]
Data from [Data independently produced by , , Int J Biochem Cell Biol, 2018, 94:107-118]
Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8] | PubMed: 38301954 |
Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis [ Redox Rep, 2023, 28(1):2152607] | PubMed: 36692085 |
Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline [ Microbiol Spectr, 2023, 11(3):e0470222] | PubMed: 37070985 |
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [ J Transl Int Med, 2023, 11(2):178-188] | PubMed: 37408574 |
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia [ Cancer Cell, 2022, S1535-6108(22)00312-9] | PubMed: 35868306 |
Nao Tan Qing ameliorates Alzheimer's disease-like pathology by regulating glycolipid metabolism and neuroinflammation: A network pharmacology analysis and biological validation [ Pharmacol Res, 2022, 185:106489] | PubMed: 36228869 |
Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies [ Int J Biol Macromol, 2022, S0141-8130(22)02224-3] | PubMed: 36252624 |
奥曲肽联合黄芩素抑制胰腺神经内分泌肿瘤细胞增殖和迁移. [ Progress in Modern Biomedicine, 2022, Vol.22] | PubMed: none |
Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses [ Adv Sci (Weinh), 2021, e2103360] | PubMed: 34918496 |
pH-dependent rearrangement determines the iron-activation and antitumor activity of artemisinins [ Free Radic Biol Med, 2021, 163:234-242] | PubMed: 33359684 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.