Home Metabolism Transferase inhibitor DL-Homocysteine For research use only.

DL-Homocysteine

DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.

DL-Homocysteine Chemical Structure

DL-Homocysteine Chemical Structure

CAS No. 454-29-5

Purity & Quality Control

DL-Homocysteine Related Products

Signaling Pathway

Transferase Signaling Pathways

Transferase Signaling Pathway

Biological Activity

Description

DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.
Targets
KYNA [1] KAT [1]
In Vivo
In vivo

In vivo peripheral application of DL-homocysteine increases Kynurenic Acid (KYNA) content in cortex and hippocampus.[2]

Chemical Information & Solubility

Molecular Weight 135.18 Formula

C4H9NO2S
CAS No. 454-29-5 SDF --
Smiles NC(CCS)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 27 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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