Home Apoptosis Caspase inhibitor Z-VAD(OH)-FMK (Caspase Inhibitor VI) For research use only.

Z-VAD(OH)-FMK (Caspase Inhibitor VI)

Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

Z-VAD(OH)-FMK (Caspase Inhibitor VI) Chemical Structure

Z-VAD(OH)-FMK (Caspase Inhibitor VI) Chemical Structure

CAS No. 161401-82-7

Purity & Quality Control

Z-VAD(OH)-FMK (Caspase Inhibitor VI) Related Products

Signaling Pathway

Caspase Signaling Pathways

Caspase Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SF188 Apoptosis assay Inhibition of 20S-protopanaxadiol-induced activation of caspases in human SF188 cells 17261067
SF188 Apoptosis assay Inhibition of TNF-alpha-induced apoptosis in human SF188 cells 17261067
SF188 Apoptosis assay Inhibition of cycloheximide-induced apoptosis in human SF188 cells 17261067
Click to View More Cell Line Experimental Data

Biological Activity

Description Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Targets
Caspase [1]
In vitro
In vitro

Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1]
Cell Research Cell lines Panc-1 cells
Concentrations 50 μM
Incubation Time 1 h
Method

Cells were treated with indicated concentration of the drug for an hour.
In Vivo
In vivo

Z-VAD-FMK is a widely used broad-spectrum caspase inhibitor that protects muscle from compression-induced damage and restores muscle function.
Animal Research Animal Models Male BALB/C mice
Dosages 1.5 mg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 453.46 Formula

C21H28FN3O7
CAS No. 161401-82-7 SDF Download Z-VAD(OH)-FMK (Caspase Inhibitor VI) SDF
Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 90 mg/mL ( (198.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 90 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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