Home Apoptosis Caspase activator - IAP inhibitor - Topoisomerase activator - Apoptosis related activator Phenoxodiol (Haginin E) For research use only.

Phenoxodiol (Haginin E)

Synonyms: Idronoxil, Dehydroequol, NV 06, PXD

Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.

Phenoxodiol (Haginin E) Chemical Structure

Phenoxodiol (Haginin E) Chemical Structure

CAS No. 81267-65-4

Purity & Quality Control

Batch: S963401 DMSO]48 mg/mL]false]Ethanol]48 mg/mL]false]Water]Insoluble]false Purity: 99.99%
99.99

Phenoxodiol (Haginin E) Related Products

Signaling Pathway

Caspase Signaling Pathways

Caspase Signaling Pathway

Biological Activity

Description Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.
Targets
Caspase [1] XIAP [1] FLIP [1] Topo II [2]
In vitro
In vitro

Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients, resistant to conventional chemotherapy, undergo apoptosis following phenoxodiol treatment. This effect is dependent upon the activation of the caspase system, inhibiting XIAP, an inhibitor of apoptosis, and disrupting FLICE inhibitory protein (FLIP) expression through the Akt signal transduction pathway. Phenoxodiol is an efficient inducer of cell death in ovarian cancer cells and sensitizes the cancer cells to Fas-mediated apoptosis.[1]
Cell Research Cell lines primary ovarian cancer cells
Concentrations 0.1 μg/ml, 1 μg/ml, 10 μg/ml
Incubation Time 24 h
Method

Cells are treated in the presence or absence of 500 ng/ml Fas-antibody in Optimem for 24 h or with 0.1, 1 or 10 μg/ml phenoxodiol, NV03, NV05 or NV07 in Optimem for 24 h. For treatment with phenoxodiol and caspase inhibitors, 10 μg/ml phenoxodiol is used alone, or in combination with 20 μM general caspase-inhibitor Z-VADFMK and incubated for 24 h.
In Vivo
In vivo

In an in vivo colon cancer model, Balb/C mice administered low-dose Phenoxodiol (PXD), exhibits significantly reduced tumour growth rates and prolonged survival (in 40% of the animals).[4]
Animal Research Animal Models 7–8-week-old female Balb/C mice
Dosages 10 mg/kg, 20 mg/kg
Administration IP
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05100628 Terminated
Metastatic Soft-tissue Sarcoma
Noxopharm Limited
 February 11 2022 Phase 1
NCT04957290 Terminated
Metastatic Castration-resistant Prostate Cancer and Other Solid Tumors
Noxopharm Limited
 October 25 2021 Phase 1|Phase 2
NCT00557037 Completed
Prostate Cancer
MEI Pharma Inc.
 November 2007 Phase 2
NCT00878800 Completed
Dose Escalation: Solid Tumors|MTD: Soft Tissue Sarcomas
Valerio Therapeutics|Spectrum Pharmaceuticals Inc
 December 2006 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 240.25 Formula

C15H12O3
CAS No. 81267-65-4 SDF --
Smiles C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 48 mg/mL ( (199.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 48 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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