Choose Your Country or Region

IAP

Isoform-selective Products

cIAP XIAP

Signaling Pathway

IAP Products

All (14)
IAP Inhibitors (9)
IAP Antagonists (5)
New IAP Products

Catalog No.	Product Name	Information	Product Use Citations
S1130	Sepantronium Bromide (YM155)	Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.	Cell Commun Signal, 2024, 22(1):440 Sci Rep, 2024, 14(1):7604 Adv Sci (Weinh), 2023, 10(25):e2301753
S7015	Birinapant	Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with K_d of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.	Cell Death Differ, 2024, 31(10):1318-1332 Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Cancer Res, 2024, 84(15):2432-2449
S7597	BV-6	BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.	Cell Rep Med, 2024, 5(1):101377 Cell Death Differ, 2024, 10.1038/s41418-024-01301-w Cell Rep, 2024, 43(9):114728
S7009	LCL161	LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).	Cell Death Dis, 2024, 15(8):592 Cell Death Dis, 2024, 15(4):255 Cell Death Dis, 2024, 15(11):855
S2754	Xevinapant (AT406)	Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.	Cell Death Dis, 2024, 15(11):855 Cells, 2023, 12(12)1653 Cells, 2023, 12(12)1653
S7010	GDC-0152	GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.	Nat Commun, 2023, 14(1):1461 Cell Rep, 2023, 42(1):111965 Cell Death Dis, 2020, 11(8):680
S7362	AZD5582	AZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15	Cell Rep, 2024, 43(7):114400 Cell Death Dis, 2023, 14(9):599 Cell Death Dis, 2023, 14(9):599
S7089	SM-164	SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.	Microbiol Spectr, 2024, 12(1):e0275823 J Biochem, 2024, mvae067 EMBO J, 2023, 42(9):e113490
S7025	Embelin	Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.	Heliyon, 2023, 9(3):e14006 Cancers (Basel), 2021, 13(14)3585 Cell Host Microbe, 2018, 24(5):689-702
S8681	Tolinapant (ASTX660)	Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.	Cell Death Differ, 2024, 31(10):1318-1332 Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Heliyon, 2023, 9(10):e20655
S5967	Berberine chloride hydrate	Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Biosci (Landmark Ed), 2022, 27(8):242 Front Pharmacol, 2021, 12:632201
S9634	Phenoxodiol (Haginin E)	Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.	Anticancer Res, 2018, 38(10):5709-5716
S2271	Berberine chloride	Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Adv Healthc Mater, 2023, e2300591. Transl Oncol, 2023, 35:101712 J Biomol Struct Dyn, 2022, 1-11
S5600	Flavokawain A	Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.
S1130	Sepantronium Bromide (YM155)	Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.	Cell Commun Signal, 2024, 22(1):440 Sci Rep, 2024, 14(1):7604 Adv Sci (Weinh), 2023, 10(25):e2301753
S7597	BV-6	BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.	Cell Rep Med, 2024, 5(1):101377 Cell Death Differ, 2024, 10.1038/s41418-024-01301-w Cell Rep, 2024, 43(9):114728
S7009	LCL161	LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).	Cell Death Dis, 2024, 15(8):592 Cell Death Dis, 2024, 15(4):255 Cell Death Dis, 2024, 15(11):855
S7362	AZD5582	AZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15	Cell Rep, 2024, 43(7):114400 Cell Death Dis, 2023, 14(9):599 Cell Death Dis, 2023, 14(9):599
S7025	Embelin	Embelin (Embelic Acid, NSC 91874), a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.	Heliyon, 2023, 9(3):e14006 Cancers (Basel), 2021, 13(14)3585 Cell Host Microbe, 2018, 24(5):689-702
S5967	Berberine chloride hydrate	Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Front Biosci (Landmark Ed), 2022, 27(8):242 Front Pharmacol, 2021, 12:632201
S9634	Phenoxodiol (Haginin E)	Phenoxodiol (Haginin E, Idronoxil, Dehydroequol, NV 06, PXD) is an isoflavone analog with antineoplastic activity that activates the caspase system, inhibits XIAP (X-linked inhibitor of apoptosis), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. Phenoxodiol also inhibits DNA topoisomerase II.	Anticancer Res, 2018, 38(10):5709-5716
S2271	Berberine chloride	Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.	Adv Healthc Mater, 2023, e2300591. Transl Oncol, 2023, 35:101712 J Biomol Struct Dyn, 2022, 1-11
S5600	Flavokawain A	Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.
S7015	Birinapant	Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with K_d of <1 nM in a cell-free assay, less potent to XIAP. Birinapant helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.	Cell Death Differ, 2024, 31(10):1318-1332 Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Cancer Res, 2024, 84(15):2432-2449
S2754	Xevinapant (AT406)	Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.	Cell Death Dis, 2024, 15(11):855 Cells, 2023, 12(12)1653 Cells, 2023, 12(12)1653
S7010	GDC-0152	GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.	Nat Commun, 2023, 14(1):1461 Cell Rep, 2023, 42(1):111965 Cell Death Dis, 2020, 11(8):680
S7089	SM-164	SM-164 is a potent, non-peptide, cell-permeable antagonist of XIAP that targets both the BIR2 and BIR3 domains with IC50 of 1.39 nM. SM-164 induces apoptosis and tumor regression.	Microbiol Spectr, 2024, 12(1):e0275823 J Biochem, 2024, mvae067 EMBO J, 2023, 42(9):e113490
S8681	Tolinapant (ASTX660)	Tolinapant (ASTX660) is a potent, non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L, respectively.	Cell Death Differ, 2024, 31(10):1318-1332 Cell Death Differ, 2024, 10.1038/s41418-024-01316-3 Heliyon, 2023, 9(10):e20655

Choose Selective IAP Inhibitors