Home Immunology & Inflammation Anti-infection inhibitor - Caspase activator - PARP modulator - P450 (e.g. CYP17) activator - IAP inhibitor - Bcl-2 inhibitor - p38 MAPK activator Berberine chloride hydrate For research use only.

Berberine chloride hydrate

Synonyms: Natural Yellow 18 chloride hydrate

Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

Berberine chloride hydrate Chemical Structure

Berberine chloride hydrate Chemical Structure

CAS No. 68030-18-2

Purity & Quality Control

Batch: S596701 Water]39 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.86%
99.86

Berberine chloride hydrate Related Products

Biological Activity

Description Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Targets
Caspase 3 [1] Caspase 8 [1] PARP [1] cytochrome c [1] c-IAP1 [1] Click to View More Targets
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06273241 Not yet recruiting
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 March 4 2024 Not Applicable
NCT05845931 Recruiting
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 May 5 2023 Not Applicable
NCT05480670 Completed
Polycystic Ovary Syndrome
Ayub Teaching Hospital
 November 1 2022 Not Applicable
NCT05463003 Completed
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 July 19 2022 Not Applicable

Chemical Information & Solubility

Molecular Weight 389.83 Formula

C20H20ClNO5
CAS No. 68030-18-2 SDF --
Smiles O.[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(OCO5)C=C4CC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 39 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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