Home Microbiology Anti-infection chemical p-Coumaric Acid For research use only.

p-Coumaric Acid

Synonyms: 4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid

p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.

p-Coumaric Acid Chemical Structure

p-Coumaric Acid Chemical Structure

CAS No. 501-98-4

Purity & Quality Control

p-Coumaric Acid Related Products

Biological Activity

Description p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.
In vitro
In vitro p-Coumaric acid is the most abundant isomer in natureand is biosynthesized from cinnamic acid by the action ofthe P450-dependent enzyme 4-cinnamic acid hydroxylase. p-Coumaric acid possesses antioxidant properties that reduce the risk of stomachcancer by suppressing the formation of carcinogenic nitrosamines. p-coumaric acid effectively suppressed endo-thelial cell migration, tube formation, and rat aorta ring sprouting. It reduces intracellular andmitochondrial reactive oxygen species production[1].
Cell Research Cell lines ECV304 cells
Concentrations 0-5 mM
Incubation Time 24 h
Method

ECV304 cells were seededat a concentration of 6.0 ×104 cells/cm2 onto 24-well plates. After specific treatment for 24 h, a final concentration of 0.5 mg/mL MTT reagent was added directly toeach well. After 2 h, the medium was removed, the formazan crystals in ECV304 cells were dissolved in dimethylsulfoxide, and the absorbance of the formazan solutionwas measured by an ELISA reader at 540 nm.
In Vivo
In vivo p-coumaric acid signif-icantly suppressed tumor growth in vivo by blockingangiogenesis[1].
Animal Research Animal Models Male BALB/c mice
Dosages 150 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 164.16 Formula

C9H8O3
CAS No. 501-98-4 SDF Download p-Coumaric Acid SDF
Smiles C1=CC(=CC=C1C=CC(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (194.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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