p-Coumaric Acid

Catalog No.S4759 Batch:S475901

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Technical Data

Formula

C9H8O3
Molecular Weight 164.16 CAS No. 501-98-4
Solubility (25°C)* In vitro DMSO 32 mg/mL (194.93 mM)
Ethanol 32 mg/mL (194.93 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description p-Coumaric acid (4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.
In vitro p-Coumaric acid is the most abundant isomer in natureand is biosynthesized from cinnamic acid by the action ofthe P450-dependent enzyme 4-cinnamic acid hydroxylase. p-Coumaric acid possesses antioxidant properties that reduce the risk of stomachcancer by suppressing the formation of carcinogenic nitrosamines. p-coumaric acid effectively suppressed endo-thelial cell migration, tube formation, and rat aorta ring sprouting. It reduces intracellular andmitochondrial reactive oxygen species production[1].
In vivo p-coumaric acid signif-icantly suppressed tumor growth in vivo by blockingangiogenesis[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    ECV304 cells

  • Concentrations

    0-5 mM

  • Incubation Time

    24 h

  • Method

    ECV304 cells were seededat a concentration of 6.0 ×104 cells/cm2 onto 24-well plates. After specific treatment for 24 h, a final concentration of 0.5 mg/mL MTT reagent was added directly toeach well. After 2 h, the medium was removed, the formazan crystals in ECV304 cells were dissolved in dimethylsulfoxide, and the absorbance of the formazan solutionwas measured by an ELISA reader at 540 nm.
Animal Study:

[1]
  • Animal Models

    Male BALB/c mice

  • Dosages

    150 mg/kg

  • Administration

    i.p.

Selleck's p-Coumaric Acid has been cited by 2 publications

Combination of HDE and BIIB021 efficiently inhibits cell proliferation and induces apoptosis via downregulating hTERT in myelodysplastic syndromes [ Exp Ther Med, 2021, 21(5):503] PubMed: 33791012
Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. [ J Nutr Biochem, 2015, 26(11):1379-84] PubMed: 26303405

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.