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Polyphyllin B (Formosanin C)

Name: Polyphyllin B (Formosanin C)
Brand: Selleck Chemicals
SKU: S3279
Rating: 5 (1 reviews)

Synonyms: FC

Catalog No.S3279 Purity:99.43%

Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.

Polyphyllin B (Formosanin C) Chemical Structure

CAS No. 50773-42-7

Purity & Quality Control

Batch: S327901 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.43%

99.43

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Biological Activity

Description	Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06211400	Not yet recruiting	Crohn Disease	University of Hertfordshire\|University of Central Lancashire\|Anglia Ruskin University\|Royal Veterinary College	July 1 2024	Not Applicable
NCT06299826	Not yet recruiting	Chronic Heart Failure	AstraZeneca	June 10 2024	Phase 2
NCT06104228	Not yet recruiting	Pulmonary Arterial Hypertension\|Idiopathic Pulmonary Arterial Hypertension\|Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)\|Connective Tissue Diseases	Bastiaan Driehuys\|American Heart Association\|Duke University	May 1 2024	Phase 2
NCT05901766	Not yet recruiting	Iodine Deficiency\|Nutrition Poor\|Development Infant\|Breastfeeding	Brigham and Women''s Hospital	May 2024	Phase 4
NCT06353633	Not yet recruiting	Inflammatory Bowel Diseases	National Nutrition and Food Technology Institute	April 10 2024	Not Applicable
NCT06122922	Withdrawn	Pulmonary Artery Hypertension	Bastiaan Driehuys\|Regeneron Pharmaceuticals\|Duke University	March 15 2024	Phase 2

References

Chemical Information & Solubility

Molecular Weight	1015.18	Formula	C₅₁H₈₂O₂₀
CAS No.	50773-42-7	SDF	--
Smiles	CC1CCC2(OC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(C)C(OC9OC(C)C(O)C(O)C9O)C(O)C8O)C(O)C7OC%10OC(C)C(O)C(O)C%10O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (98.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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