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Formula | C21H28FN3O7 |
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Molecular Weight | 453.46 | CAS No. | 161401-82-7 | |
Solubility (25°C)* | In vitro | DMSO | 90 mg/mL (198.47 mM) | |
Ethanol | 90 mg/mL (198.47 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. | |
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In vitro | Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1] |
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In vivo | Z-VAD-FMK is a widely used broad-spectrum caspase inhibitor that protects muscle from compression-induced damage and restores muscle function. |
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Data from [Data independently produced by , , Med Oncol, 2015, 32(4):100. ]
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [ Cell, 2024, 187(15):4043-4060.e30] | PubMed: 38878778 |
Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA [ J Ethnopharmacol, 2024, 328:118057] | PubMed: 38518965 |
Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells [ Toxins (Basel), 2024, 16(1)61] | PubMed: 38276537 |
Intracellular biliverdin dynamics during ferroptosis [ J Biochem, 2024, mvae067] | PubMed: 39340324 |
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis [ Commun Biol, 2023, 6(1):1271] | PubMed: 38102401 |
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors [ Cell Death Dis, 2022, 13(11):1000] | PubMed: 36435804 |
Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy [ Free Radic Biol Med, 2022, S0891-5849(22)00222-2] | PubMed: 35675856 |
Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation [ Int J Mol Sci, 2022, 23(16)8839] | PubMed: 36012104 |
Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells [ Int J Biol Sci, 2021, 17(2):589-602] | PubMed: 33613115 |
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer [ Cell Death Dis, 2021, 12(2):140] | PubMed: 33542218 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.