Home Cell Cycle CDK inhibitor - JAK inhibitor - FLT3 inhibitor Zotiraciclib For research use only.

Zotiraciclib

Synonyms: SB1317 (TG02)

Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.

Zotiraciclib Chemical Structure

Zotiraciclib Chemical Structure

CAS No. 937270-47-8

Purity & Quality Control

Batch: S700201 DMSO]15 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.98%
99.98

Zotiraciclib Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.
Features TG02 adopts a slightly different preferred conformation in order to achieve the key interaction with Asp698 when docks into FLT3.
Targets
CDK9 [1] CDK2 [1] CDK1 [1] FLT3 [1] JAK2 [1]
3 nM 5 nM 9 nM 19 nM 19 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05588141 Recruiting
Brain Tumor|Cancer
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 May 16 2023 Phase 1|Phase 2
NCT02942264 Completed
Brain Tumor|Astrocytoma|Astroglioma|Glioblastoma|Gliosarcoma
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 December 14 2016 Phase 1|Phase 2
NCT01204164 Completed
AML|ALL|Blast Crisis|MDS|Multiple Myeloma
Tragara Pharmaceuticals Inc.
 August 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 372.46 Formula

C23H24N4O
CAS No. 937270-47-8 SDF --
Smiles CN1C/C=C/CCOC2=CC(=CC=C2)C3=CC=NC(=NC4=CC=CC(=C4)C1)N3
Storage (From the date of receipt) 3 years-21°C powder

In vitro
Batch:

DMSO : 15 mg/mL ( (40.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Zotiraciclib | Zotiraciclib supplier | purchase Zotiraciclib | Zotiraciclib cost | Zotiraciclib manufacturer | order Zotiraciclib | Zotiraciclib distributor