Home Cell Cycle CDK inhibitor PF-06873600 For research use only.

PF-06873600

PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively, blocks the phosphorylation of retinoblastoma protein (RB1), and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.

PF-06873600 Chemical Structure

PF-06873600 Chemical Structure

CAS No. 2185857-97-8

Purity & Quality Control

Products often used together with PF-06873600

Fadraciclib (CYC065)

PF-06873600 and Fadraciclib efficiently inhibit growth of both sensitive and aromatase inhibitor (AI)-resistant cells.

Al-Qasem AJ, et al. NPJ Precis Oncol. 2022 Sep 24;6(1):68.

Dinaciclib

PF-06873600 and Dinaciclib treatment dampens induction of gammaH2AX in FT282-hTERT cells.

Gallo D, et al. Nature. 2022 Apr;604(7907):749-756.

Tagtociclib (PF-07104091)

PF-06873600 and PF-07104091 are used to understand the relationship between pNPAT and nascent histone mRNA in MCF10A cells.

Armstrong C, et al. Cell Rep. 2023 Jul 25;42(7):112768.

PF-06873600 Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively, blocks the phosphorylation of retinoblastoma protein (RB1), and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.
Targets
CDK2 [1]
(in a mobility shift assay (MSA))		 CDK6 [1]
(in a mobility shift assay (MSA))		 CDK4 [1]
(in a mobility shift assay (MSA))
0.1 nM(Ki) 0.1 nM(Ki) 1.2 nM(Ki)
In vitro
In vitro

PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively.

Chemical Information & Solubility

Molecular Weight 471.52 Formula

C20H27F2N5O4S
CAS No. 2185857-97-8 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 94 mg/mL ( (199.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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