Home Cell Cycle CDK inhibitor Simurosertib For research use only.

Simurosertib

Synonyms: TAK-931

Simurosertib (TAK-931), an oral cell division cycle 7 (CDC7)-selective inhibitor with an IC50<0.3 nM, induces S phase delay and replication stress and causes mitotic aberrations through centrosome dysregulation and chromosome missegregation, resulting in irreversible antiproliferative effects in cancer cells.

Simurosertib Chemical Structure

Simurosertib Chemical Structure

CAS No. 1330782-76-7

Purity & Quality Control

Batch: S892501 DMSO]68 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.79%
99.79

Simurosertib Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description Simurosertib (TAK-931), an oral cell division cycle 7 (CDC7)-selective inhibitor with an IC50<0.3 nM, induces S phase delay and replication stress and causes mitotic aberrations through centrosome dysregulation and chromosome missegregation, resulting in irreversible antiproliferative effects in cancer cells.
Targets
Cdc7 [1]
(in CDC7 enzyme assay)
0.3 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03708211 Completed
Neoplasms Advanced Solid
Millennium Pharmaceuticals Inc.|Takeda
 March 28 2019 Phase 1
NCT03261947 Completed
Metastatic Pancreatic Cancer|Colorectal Cancer|Esophageal Neoplasms|Carcinoma Non-small-cell Lung
Millennium Pharmaceuticals Inc.|Takeda
 October 25 2017 Phase 2
NCT02699749 Completed
Nonhematologic Neoplasms Advanced
Millennium Pharmaceuticals Inc.|Takeda
 March 24 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 341.43 Formula

C17H19N5OS
CAS No. 1330782-76-7 SDF --
Smiles CC1=C(C=NN1)C2=CC3=C(S2)C(=O)NC(=N3)C4CC5CCN4CC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (199.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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