Home Metabolism CDK inhibitor - phosphatase inhibitor NSC95397 For research use only.

NSC95397

NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.

NSC95397 Chemical Structure

NSC95397 Chemical Structure

CAS No. 93718-83-3

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NSC95397 Related Products

Signaling Pathway

CDK Signaling Pathways

CDK Signaling Pathway

Biological Activity

Description NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
Targets
MKP-1 [2] Cdc25A [1]
(Cell-free assay)		 Cdc25A [1]
(Cell-free assay)		 Cdc25C [1]
(Cell-free assay)		 Cdc25B [1]
(Cell-free assay)		 Click to View More Targets
22.3 nM 32 nM(Ki) 40 nM(Ki) 56.9 nM

Chemical Information & Solubility

Molecular Weight 310.39 Formula

C14H14O4S2
CAS No. 93718-83-3 SDF --
Smiles C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 62 mg/mL ( (199.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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