PF-06873600

Catalog No.S8816 Batch:S881602

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Technical Data

Formula

C20H27F2N5O4S
Molecular Weight 471.52 CAS No. 2185857-97-8
Solubility (25°C)* In vitro DMSO 94 mg/mL (199.35 mM)
Ethanol 3 mg/mL (6.36 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively, blocks the phosphorylation of retinoblastoma protein (RB1), and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.
Targets
CDK2 [1]
(in a mobility shift assay (MSA))		 CDK6 [1]
(in a mobility shift assay (MSA))		 CDK4 [1]
(in a mobility shift assay (MSA))
0.1 nM(Ki) 0.1 nM(Ki) 1.2 nM(Ki)
In vitro

PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively.

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Mice-bearing OVCAR3 tumors

  • Dosages

    50 mg/kg

  • Administration

    p.o.

Selleck's PF-06873600 has been cited by 3 publications

Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer [ Nat Commun, 2023, 14(1):6796] PubMed: 37880211
Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer [ Nat Commun, 2023, 10.1038/s41467-023-42504-y] PubMed: 37880211
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity [ PLoS One, 2022, 17(9):e0273182] PubMed: 36067171

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.