Home TGF-beta/Smad TGF-beta/Smad inhibitor PF-06952229 For research use only.

PF-06952229

Synonyms: UNII-1KKS7U3X86

PF-06952229(UNII-1KKS7U3X86) is a selective, orally available inhibitor of the serine/threonine kinase TGF-β receptor 1 (TGF-β-R1). It inhibits pSMAD2 in both tumor and immune cells, reducing TGF-β signalling and reversing EMT in vitro. It modulates the tumor immune microenvironment and shows antitumor activity in mouse models.

PF-06952229 Chemical Structure

PF-06952229 Chemical Structure

CAS No. 1801333-55-0

Purity & Quality Control

Batch: E178501 DMSO]92 mg/mL]false]Ethanol]92 mg/mL]false]Water]Insoluble]false Purity: 98.29%
98.29

PF-06952229 Related Products

Signaling Pathway

TGF-beta/Smad Signaling Pathways

TGF-beta/Smad Signaling Pathway

Biological Activity

Description PF-06952229(UNII-1KKS7U3X86) is a selective, orally available inhibitor of the serine/threonine kinase TGF-β receptor 1 (TGF-β-R1). It inhibits pSMAD2 in both tumor and immune cells, reducing TGF-β signalling and reversing EMT in vitro. It modulates the tumor immune microenvironment and shows antitumor activity in mouse models.

Chemical Information & Solubility

Molecular Weight 458.91 Formula

C23H24ClFN4O3
CAS No. 1801333-55-0 SDF Download PF-06952229 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (200.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 92 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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