Home TGF-beta/Smad -Stem Cells & Wnt TGF-beta/Smad TGFβRII Selective Inhibitors
  • ALK1
  • ALK2
  • ALK3
  • ALK4
  • TGFβRI/ALK5
  • ALK6
  • TGFβRII
  • TGF-β
  • Smad3
  • Smad4
  • Smad5
  • ALK7

TGFβRII Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6807 TA-02 TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. Selective
S2704 LY2109761 LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis. Pan TβRII, Ki: 300 nM
S2805 LY364947 LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II. Pan TGFβRII, IC50: 0.4 μM