Home Transmembrane Transporters Calcium Channel inhibitor Panaxadiol For research use only.

Panaxadiol

Synonyms: 20(R)-Panaxadiol

Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Panaxadiol Chemical Structure

Panaxadiol Chemical Structure

CAS No. 19666-76-3

Purity & Quality Control

Batch: S384501 Ethanol]22 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.39%
99.39

Panaxadiol Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
In vitro
In vitro Panaxadiol enhances the anti-cancer eVects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells[1]. Panaxadiol inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 µM in SK-HEP-1 cells and HeLa cells. Panaxadiol-treated cells are arrested at G 1/S phase, which coincides well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 are significantly and selectively elevated in a dose- and time-dependent manner in panaxadiol-treated HeLa cells[2].
Cell Research Cell lines HCT-116
Concentrations 5, 15, or 25 μM
Incubation Time 24 and 48 h
Method

HCT-116 cells are incubated with varying concentrations of 5-FU (5, 10, 20, 30, 50, or 100 μM) and panaxadiol (5, 15, or 25 μM) for 24 and 48 h.

Chemical Information & Solubility

Molecular Weight 460.73 Formula

C30H52O3
CAS No. 19666-76-3 SDF Download Panaxadiol SDF
Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 22 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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