Home Transmembrane Transporters Calcium Channel antagonist Imperatorin For research use only.

Imperatorin

Synonyms: Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen, 8-Isopentenyloxypsoralene

Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.

Imperatorin Chemical Structure

Imperatorin Chemical Structure

CAS No. 482-44-0

Purity & Quality Control

Batch: S380901 DMSO]54 mg/mL]false]]]false]]]false Purity: 98%
98

Imperatorin Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.
In vitro
In vitro Imperatorin has estrogen-like activities in MCF-7 cells and stimulatory effects on ALP activity of Saos-2 osteoblast cells[1].
Cell Research Cell lines MCF-7 cells
Concentrations 0.1 μmol/L
Incubation Time 24 h
Method

The MCF-7 cells are seeded into six-well plates in standard growth medium at a density of 100 000 cells per well and allowed to attach overnight (24 h). The growth medium is replaced with phenol red free DMEM containing 10% charcoal-dextran stripped human serum (hormone-free) for 72 h, after which the medium is refreshed and chemicals are added. After a further 24-h exposure, the cells are harvested and washed with PBS. Cell pellets, which are obtained by centrifugation at 1000 rpm for 15 minutes, are stained with 1 mL of freshly propidium iodide (PI) staining solution (0.1% of Triton X-100, 0.1% of sodium citrate, 50 μg/mL of PI and 10 μg/mL of RNase A in PBS). Flow cytometric analysis of cell cycle distribution is performed.
In Vivo
In vivo Imperatorin acutely administered at the doses of 10 and 20 mg/kg impairs anxiogenic effect of nicotine in the elevated plus maze (EPM) test. Imperatorin acts as irreversible inactivator of GABA-transaminase and increases the GABA content in the brain. Co-administration of subthreshold doses of imperatorin and nicotine produces an improvement inmemory processes in animals[2].
Animal Research Animal Models male Swiss mice
Dosages 1, 10 and 20 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 270.28 Formula

C16H14O4
CAS No. 482-44-0 SDF Download Imperatorin SDF
Smiles CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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