Home Transmembrane Transporters Calcium Channel inhibitor Manidipine For research use only.

Manidipine

Synonyms: CV-4093,(±)-Manidipine

Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.

Manidipine Chemical Structure

Manidipine Chemical Structure

CAS No. 89226-50-6

Purity & Quality Control

Manidipine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
Targets
Calcium channel [1]
2.6 nM
In vitro
In vitro

Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer. [1] Manidipine inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). Manidipine (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. Manidipine is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that Manidipine has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response. [2]
In Vivo
In vivo

Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. [3] Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. [4] Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats. [5]

Chemical Information & Solubility

Molecular Weight 610.7 Formula

C35H38N4O6

CAS No. 89226-50-6 SDF Download Manidipine SDF
Smiles CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 122 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

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