Home Transmembrane Transporters Calcium Channel inhibitor Cinnarizine For research use only.

Cinnarizine

Synonyms: Stugeron, Dimitronal, Stutgin, Cinarizine

Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

Cinnarizine Chemical Structure

Cinnarizine Chemical Structure

CAS No. 298-57-7

Purity & Quality Control

Batch: S472701 DMSO]9.1 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.96%
99.96

Cinnarizine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Biological Activity

Description Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
Targets
Calcium channel [1] Histamine receptor [3]
In vitro
In vitro Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists[3].
Cell Research Cell lines mouse B16 melanoma cells(4A5)
Concentrations 0.625, 1.25, 2.5, 5, 10, 20 μM
Incubation Time 48 h
Method MTT assay is performed to examine the viability of cells. Afterwards, the cells are incubated with the samples for 48 h, the culture medium is removed and replaced with 1 mg/mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h. The MTT solution is then removed and DMSO was added, following which the absorbance of the dissolved formazan crystals is determined at 570 nm by a spectrophotometer.
In Vivo
In vivo Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures[2]. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism[3]. Its half-life is 4 hours.
Animal Research Animal Models Male albino mice
Dosages 30 mg/kg
Administration i.p

Chemical Information & Solubility

Molecular Weight 368.51 Formula

C26H28N2
CAS No. 298-57-7 SDF Download Cinnarizine SDF
Smiles C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 9.1 mg/mL ( (24.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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